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    Rfc1 replication factor C (activator 1) 1 [ Mus musculus (house mouse) ]

    Gene ID: 19687, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rfc1provided by MGI
    Official Full Name
    replication factor C (activator 1) 1provided by MGI
    Primary source
    MGI:MGI:97891
    See related
    Ensembl:ENSMUSG00000029191 AllianceGenome:MGI:97891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Recc1; 140kDa; Alp145; RFC140
    Summary
    Predicted to enable several functions, including DNA binding activity; DNA clamp unloader activity; and DNA-binding transcription factor binding activity. Predicted to be involved in DNA-templated DNA replication; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in West Nile fever and congenital heart disease. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.8), limb E14.5 (RPKM 8.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rfc1 in Genome Data Viewer
    Location:
    5 C3.1; 5 33.61 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65419195..65492988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65261852..65338617, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene kelch-like 5 Neighboring gene predicted gene, 54287 Neighboring gene STARR-positive B cell enhancer ABC_E849 Neighboring gene WD repeat domain 19 Neighboring gene STARR-seq mESC enhancer starr_13260 Neighboring gene STARR-positive B cell enhancer ABC_E6334 Neighboring gene klotho beta Neighboring gene STARR-positive B cell enhancer ABC_E3577 Neighboring gene ribosomal protein L9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evaluation of inter- and intramolecular primary structure homologies of interferons by a Monte Carlo method. Wagner F, et al. J Interferon Res, 1990 Feb. PMID 1691767
    2. Genetic mapping of gene encoding the large subunit of replication factor C (A1-p145) to mouse chromosome 5. Lyu MS, et al. Mamm Genome, 1995 Jul. PMID 7579896
    3. Differentiation-specific element binding protein (DSEB) binds to a defined element in the promoter of the angiotensinogen gene required for the irreversible induction of gene expression during differentiation of 3T3-L1 adipoblasts to adipocytes. McGehee RE Jr, et al. Mol Endocrinol, 1995 Apr. PMID 7659092
    4. Cloning of the murine cDNA encoding VDJP, a protein homologous to the large subunit of replication factor C and bacterial DNA ligases. Halligan BD, et al. Gene, 1995 Aug 19. PMID 7665082
    5. Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases. Burbelo PD, et al. Proc Natl Acad Sci U S A, 1993 Dec 15. PMID 8265586, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC96526

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp unloader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA clamp unloader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA clamp unloader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA clamp unloading IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor C complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Elg1 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Elg1 RFC-like complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 1
    Names
    A1 140 kDa subunit
    A1-P145
    ISRE-binding protein
    RF-C 140 kDa subunit
    activator 1 140 kDa subunit
    activator 1 large subunit
    activator 1 subunit 1
    differentiation-specific element-binding protein
    replication factor C 1
    replication factor C 140 kDa subunit
    replication factor C large subunit
    replication factor C, 140 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347357.2 → NP_001334286.1  replication factor C subunit 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC138654
      Consensus CDS
      CCDS84885.1
      UniProtKB/Swiss-Prot
      P35601
      UniProtKB/TrEMBL
      G3UXL4, Q5U4B1
      Related
      ENSMUSP00000144954.2, ENSMUST00000203471.3

    2. NM_001347358.2 → NP_001334287.1  replication factor C subunit 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC138654
      Consensus CDS
      CCDS84884.1
      UniProtKB/Swiss-Prot
      P35601
      UniProtKB/TrEMBL
      A0A0N5E9G7
      Related
      ENSMUSP00000134444.5, ENSMUST00000172732.8

    3. NM_001421208.1 → NP_001408137.1  replication factor C subunit 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC138654

    4. NM_001421209.1 → NP_001408138.1  replication factor C subunit 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC138654
      UniProtKB/TrEMBL
      G3UWX1
      Related
      ENSMUSP00000145385.2, ENSMUST00000203581.3

    5. NM_011258.3 → NP_035388.2  replication factor C subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_035388.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC138654
      Consensus CDS
      CCDS39096.1
      UniProtKB/Swiss-Prot
      P35601
      UniProtKB/TrEMBL
      G3UZD0, G3X8Z6
      Related
      ENSMUSP00000144980.2, ENSMUST00000204965.3
      Conserved Domains (4) summary
      smart00382
      Location:632 → 762
      AAA; ATPases associated with a variety of cellular activities
      cd00027
      Location:406 → 477
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam00004
      Location:632 → 760
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam08519
      Location:899 → 1052
      RFC1; Replication factor RFC1 C terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      65419195..65492988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35601.2 GenPept UniProtKB/Swiss-Prot:P35601

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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