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    Kif1a kinesin family member 1A [ Mus musculus (house mouse) ]

    Gene ID: 16560, updated on 27-Nov-2024

    Summary

    Official Symbol
    Kif1aprovided by MGI
    Official Full Name
    kinesin family member 1Aprovided by MGI
    Primary source
    MGI:MGI:108391
    See related
    Ensembl:ENSMUSG00000014602 AllianceGenome:MGI:108391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATSV; Kns1; Gm1626; C630002N23Rik
    Summary
    Enables microtubule binding activity. Involved in anterograde synaptic vesicle transport. Located in neuron projection and neuronal cell body. Is expressed in genitourinary system; nervous system; and sensory organ. Used to study hereditary spastic paraplegia 30. Human ortholog(s) of this gene implicated in NESCAV syndrome; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 79.2), frontal lobe adult (RPKM 72.1) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kif1a in Genome Data Viewer
    Location:
    1 D; 1 46.74 cM
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92943180..93029760, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93015455..93102039, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57553 Neighboring gene aquaporin 12 Neighboring gene STARR-seq mESC enhancer starr_01723 Neighboring gene predicted gene, 36472 Neighboring gene alanine-glyoxylate aminotransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Spontaneous (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anterograde neuronal dense core vesicle transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anterograde synaptic vesicle transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dense core granule cytoskeletal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dense core granule cytoskeletal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interkinetic nuclear migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde neuronal dense core vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde neuronal dense core vesicle transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal dense core vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal dense core vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF1A
    Names
    N-3 kinesin
    axonal transporter of synaptic vesicles
    kinesin heavy chain member 1A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110315.3NP_001103785.1  kinesin-like protein KIF1A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC110247, AC119846
      Consensus CDS
      CCDS48326.1
      UniProtKB/TrEMBL
      E9QAN4, Q6P5H4
      Related
      ENSMUSP00000130717.2, ENSMUST00000171556.8
      Conserved Domains (7) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15701672
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:598676
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11481295
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    2. NM_001294149.2NP_001281078.1  kinesin-like protein KIF1A isoform c

      Status: VALIDATED

      Source sequence(s)
      AC110247, AC119846
      Consensus CDS
      CCDS78651.1
      UniProtKB/TrEMBL
      E9Q9G6, Q3UH16
      Related
      ENSMUSP00000108582.3, ENSMUST00000112958.9
      Conserved Domains (7) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15791681
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:598676
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11481304
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    3. NM_001294150.2NP_001281079.1  kinesin-like protein KIF1A isoform d

      See identical proteins and their annotated locations for NP_001281079.1

      Status: VALIDATED

      Source sequence(s)
      AC110247, AC119846
      Consensus CDS
      CCDS78652.1
      UniProtKB/TrEMBL
      Q6P5H4, Q6TA13
      Related
      ENSMUSP00000084029.6, ENSMUST00000086819.12
      Conserved Domains (7) summary
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15791681
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:607685
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:814860
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11571304
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated
    4. NM_001368847.2NP_001355776.1  kinesin-like protein KIF1A isoform e

      Status: VALIDATED

      Source sequence(s)
      AC110247, AC119846
      UniProtKB/Swiss-Prot
      P33173, Q61770
      Conserved Domains (7) summary
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15871689
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:607685
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:814860
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11571312
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated
    5. NM_001408925.1NP_001395854.1  kinesin-like protein KIF1A isoform f

      Status: VALIDATED

      Source sequence(s)
      AC110247, AC119846
      UniProtKB/TrEMBL
      A0A087WQE8
      Related
      ENSMUSP00000140163.2, ENSMUST00000190723.7
    6. NM_008440.5NP_032466.2  kinesin-like protein KIF1A isoform a

      See identical proteins and their annotated locations for NP_032466.2

      Status: VALIDATED

      Source sequence(s)
      AC110247, AC119846
      Consensus CDS
      CCDS48327.1
      UniProtKB/Swiss-Prot
      P33173, Q61770
      UniProtKB/TrEMBL
      G3UW47
      Related
      ENSMUSP00000128432.2, ENSMUST00000171796.8
      Conserved Domains (7) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15781680
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:598676
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11481303
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      92943180..93029760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529155.5XP_006529218.1  kinesin-like protein KIF1A isoform X1

      UniProtKB/TrEMBL
      Q3UH16
      Conserved Domains (7) summary
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16811783
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:607685
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:814861
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12501406
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated
    2. XM_036162306.1XP_036018199.1  kinesin-like protein KIF1A isoform X6

      UniProtKB/TrEMBL
      Q3UH16
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16641766
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12331389
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    3. XM_036162307.1XP_036018200.1  kinesin-like protein KIF1A isoform X7

      UniProtKB/TrEMBL
      Q6P5H4
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16631765
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12411388
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    4. XM_006529159.5XP_006529222.1  kinesin-like protein KIF1A isoform X5

      UniProtKB/TrEMBL
      Q3UH16
      Conserved Domains (7) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16721774
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:598676
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:805852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12411397
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    5. XM_006529160.5XP_006529223.1  kinesin-like protein KIF1A isoform X8

      UniProtKB/TrEMBL
      Q3UH16
      Conserved Domains (7) summary
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15881690
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:607685
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:814860
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11571313
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated
    6. XM_006529157.5XP_006529220.1  kinesin-like protein KIF1A isoform X3

      UniProtKB/TrEMBL
      Q3UH16
      Conserved Domains (7) summary
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16731775
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:607685
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:814861
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12421398
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated
    7. XM_006529156.5XP_006529219.1  kinesin-like protein KIF1A isoform X2

      UniProtKB/Swiss-Prot
      P33173, Q61770
      Conserved Domains (7) summary
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16801782
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam04502
      Location:607685
      DUF572; Family of unknown function (DUF572)
      pfam12423
      Location:814861
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12501405
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated