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    Oard1 O-acyl-ADP-ribose deacylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 106821, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Oard1provided by MGI
    Official Full Name
    O-acyl-ADP-ribose deacylase 1provided by MGI
    Primary source
    MGI:MGI:2146818
    See related
    Ensembl:ENSMUSG00000040771 AllianceGenome:MGI:2146818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable O-acetyl-ADP-ribose deacetylase activity; hydrolase activity, hydrolyzing N-glycosyl compounds; and purine nucleoside binding activity. Predicted to be involved in DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to be located in nucleolus and site of DNA damage. Predicted to be active in nucleoplasm. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 14.3), CNS E11.5 (RPKM 13.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Oard1 in Genome Data Viewer
    Location:
    17 C; 17 23.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48717028..48724298)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48409957..48417270)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene nuclear transcription factor-Y alpha Neighboring gene STARR-positive B cell enhancer ABC_E10961 Neighboring gene STARR-positive B cell enhancer ABC_E2492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48549466-48549575 Neighboring gene STARR-positive B cell enhancer ABC_E7541 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 Neighboring gene STARR-seq mESC enhancer starr_42751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48567545-48567654 Neighboring gene predicted gene, 30283 Neighboring gene VISTA enhancer mm243 Neighboring gene translocator protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2. Ito H, et al. Dev Neurosci, 2018. PMID 30227424
    2. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribosylglutamate hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ADP-ribosylglutamate hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables O-acetyl-ADP-ribose deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-acetyl-ADP-ribose deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables purine nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine nucleoside binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-glutamate ADP-deribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-glutamate ADP-deribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein de-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein de-ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in purine nucleoside metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleoside metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribose glycohydrolase OARD1
    Names
    O-acetyl-ADP-ribose deacetylase 1
    [Protein ADP-ribosylglutamate] hydrolase OARD1
    terminal ADP-ribose protein glycohydrolase 1
    NP_001276419.1
    NP_001276420.1
    NP_001344832.1
    NP_001344833.1
    NP_001400515.1
    NP_001400516.1
    NP_001400517.1
    NP_001400518.1
    NP_001400520.1
    NP_001400521.1
    NP_001400522.1
    NP_001400523.1
    NP_001400524.1
    NP_997102.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289490.1 → NP_001276419.1  ADP-ribose glycohydrolase OARD1 isoform 1

      See identical proteins and their annotated locations for NP_001276419.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164, AK153512, AW558560, BC157987, BY741306
      Consensus CDS
      CCDS37647.1
      UniProtKB/Swiss-Prot
      Q3U5M3, Q8R5F3
      Related
      ENSMUSP00000130802.2, ENSMUST00000167180.8
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    2. NM_001289491.1 → NP_001276420.1  ADP-ribose glycohydrolase OARD1 isoform 1

      See identical proteins and their annotated locations for NP_001276420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164, AK153512, AW558560
      Consensus CDS
      CCDS37647.1
      UniProtKB/Swiss-Prot
      Q3U5M3, Q8R5F3
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    3. NM_001357903.1 → NP_001344832.1  ADP-ribose glycohydrolase OARD1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164
      Consensus CDS
      CCDS37647.1
      UniProtKB/Swiss-Prot
      Q3U5M3, Q8R5F3
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    4. NM_001357904.1 → NP_001344833.1  ADP-ribose glycohydrolase OARD1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164, AW558560, BQ553673
      Consensus CDS
      CCDS37647.1
      UniProtKB/Swiss-Prot
      Q3U5M3, Q8R5F3
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    5. NM_001413586.1 → NP_001400515.1  ADP-ribose glycohydrolase OARD1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166164
      UniProtKB/Swiss-Prot
      Q3U5M3, Q8R5F3

    6. NM_001413587.1 → NP_001400516.1  ADP-ribose glycohydrolase OARD1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166164
      UniProtKB/Swiss-Prot
      Q3U5M3, Q8R5F3

    7. NM_001413588.1 → NP_001400517.1  ADP-ribose glycohydrolase OARD1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166164
      UniProtKB/Swiss-Prot
      Q3U5M3, Q8R5F3

    8. NM_001413589.1 → NP_001400518.1  ADP-ribose glycohydrolase OARD1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166164
      UniProtKB/Swiss-Prot
      Q3U5M3, Q8R5F3

    9. NM_001413591.1 → NP_001400520.1  ADP-ribose glycohydrolase OARD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166164

    10. NM_001413592.1 → NP_001400521.1  ADP-ribose glycohydrolase OARD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166164

    11. NM_001413593.1 → NP_001400522.1  ADP-ribose glycohydrolase OARD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166164

    12. NM_001413594.1 → NP_001400523.1  ADP-ribose glycohydrolase OARD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166164

    13. NM_001413595.1 → NP_001400524.1  ADP-ribose glycohydrolase OARD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166164

    14. NM_207219.4 → NP_997102.2  ADP-ribose glycohydrolase OARD1 isoform 1

      See identical proteins and their annotated locations for NP_997102.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164, AK153512, AW558560
      Consensus CDS
      CCDS37647.1
      UniProtKB/Swiss-Prot
      Q3U5M3, Q8R5F3
      Related
      ENSMUSP00000039280.7, ENSMUST00000046651.7
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    RNA

    1. NR_182169.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166164

    2. NR_182170.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166164

    3. NR_182171.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166164

    4. NR_182172.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166164

    5. NR_182173.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166164

    6. NR_182174.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166164

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48717028..48724298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939457.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R5F3.2 GenPept UniProtKB/Swiss-Prot:Q8R5F3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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