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    Pkd2l2 polycystic kidney disease 2-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 53871, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pkd2l2provided by MGI
    Official Full Name
    polycystic kidney disease 2-like 2provided by MGI
    Primary source
    MGI:MGI:1858231
    See related
    Ensembl:ENSMUSG00000014503 AllianceGenome:MGI:1858231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRPP5
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to be active in membrane. Is expressed in several structures, including cochlea; pancreas; reproductive system; spleen; and stomach. Orthologous to human PKD2L2 (polycystin 2 like 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.3), CNS E18 (RPKM 6.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pkd2l2 in Genome Data Viewer
    Location:
    18 B1; 18 18.62 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34541553..34575842)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34408501..34442798)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E8999 Neighboring gene SET translocation pseudogene Neighboring gene family with sequence similarity 13, member B Neighboring gene STARR-seq mESC enhancer starr_44201 Neighboring gene STARR-seq mESC enhancer starr_44203 Neighboring gene STARR-seq mESC enhancer starr_44204 Neighboring gene STARR-seq mESC enhancer starr_44205 Neighboring gene STARR-seq mESC enhancer starr_44207 Neighboring gene wingless-type MMTV integration site family, member 8A Neighboring gene STARR-positive B cell enhancer mm9_chr18:34732422-34732722 Neighboring gene NME/NM23 family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of Pkd2l2 in testis is implicated in spermatogenesis. Chen Y, et al. Biol Pharm Bull, 2008 Aug. PMID 18670078
    2. Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Guo L, et al. Genomics, 2000 Mar 15. PMID 10756092
    3. Polycystin-2 expression and function in adult mouse lacrimal acinar cells. Kaja S, et al. Invest Ophthalmol Vis Sci, 2011 Jul 29. PMID 21508103, Free PMC Article
    4. Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. Wu X, et al. PLoS One, 2016. PMID 27196058, Free PMC Article
    5. Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. LopezJimenez ND, et al. J Neurochem, 2006 Jul. PMID 16805797

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polycystin-2-like protein 2
    Names
    Polycystin - L2
    polycystic kidney disease 2-like 2 protein
    polycystin-2L2
    polycystin-L2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163004.1 → NP_001156476.1  polycystin-2-like protein 2

      See identical proteins and their annotated locations for NP_001156476.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC090534, AK133423, BC138717
      Consensus CDS
      CCDS29127.1
      UniProtKB/Swiss-Prot
      B2RS50, Q9JLG4
      UniProtKB/TrEMBL
      Q3V056
      Related
      ENSMUSP00000127257.2, ENSMUST00000166156.9
      Conserved Domains (1) summary
      pfam08016
      Location:76 → 497
      PKD_channel; Polycystin cation channel

    2. NM_016927.3 → NP_058623.2  polycystin-2-like protein 2

      See identical proteins and their annotated locations for NP_058623.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC090534, AC115305, BC138717
      Consensus CDS
      CCDS29127.1
      UniProtKB/Swiss-Prot
      B2RS50, Q9JLG4
      UniProtKB/TrEMBL
      Q3V056
      Related
      ENSMUSP00000014647.8, ENSMUST00000014647.9
      Conserved Domains (1) summary
      pfam08016
      Location:76 → 497
      PKD_channel; Polycystin cation channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34541553..34575842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317946.3 → XP_017173435.1  polycystin-2-like protein 2 isoform X3

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:28 → 449
      PKD_channel; Polycystin cation channel

    2. XM_017317949.3 → XP_017173438.1  polycystin-2-like protein 2 isoform X6

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:1 → 407
      PKD_channel; Polycystin cation channel

    3. XM_017317950.3 → XP_017173439.1  polycystin-2-like protein 2 isoform X6

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:1 → 407
      PKD_channel; Polycystin cation channel

    4. XM_017317944.3 → XP_017173433.1  polycystin-2-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:78 → 499
      PKD_channel; Polycystin cation channel

    5. XM_017317948.3 → XP_017173437.1  polycystin-2-like protein 2 isoform X5

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:78 → 442
      PKD_channel; Polycystin cation channel

    6. XM_036161210.1 → XP_036017103.1  polycystin-2-like protein 2 isoform X2

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:43 → 463
      PKD_channel; Polycystin cation channel

    7. XM_017317947.3 → XP_017173436.1  polycystin-2-like protein 2 isoform X3

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:28 → 449
      PKD_channel; Polycystin cation channel

    8. XM_006526097.5 → XP_006526160.1  polycystin-2-like protein 2 isoform X4

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:78 → 499
      PKD_channel; Polycystin cation channel

    9. XM_036161212.1 → XP_036017105.1  polycystin-2-like protein 2 isoform X7

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:79 → 499
      PKD_channel; Polycystin cation channel

    10. XM_017317951.3 → XP_017173440.1  polycystin-2-like protein 2 isoform X7

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:79 → 499
      PKD_channel; Polycystin cation channel

    11. XM_006526101.5 → XP_006526164.1  polycystin-2-like protein 2 isoform X7

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:79 → 499
      PKD_channel; Polycystin cation channel

    12. XM_006526104.4 → XP_006526167.1  polycystin-2-like protein 2 isoform X8

      UniProtKB/TrEMBL
      Q3UQ78
      Conserved Domains (1) summary
      pfam08016
      Location:78 → 281
      PKD_channel; Polycystin cation channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLG4.2 GenPept UniProtKB/Swiss-Prot:Q9JLG4

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