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    Mettl21a methyltransferase 21A, HSPA lysine [ Mus musculus (house mouse) ]

    Gene ID: 67099, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mettl21aprovided by MGI
    Official Full Name
    methyltransferase 21A, HSPA lysineprovided by MGI
    Primary source
    MGI:MGI:1914349
    See related
    Ensembl:ENSMUSG00000025956 AllianceGenome:MGI:1914349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam119a; 2310038H17Rik
    Summary
    Predicted to enable ATPase binding activity; Hsp70 protein binding activity; and protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human METTL21A (methyltransferase 21A, HSPA lysine). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.7), limb E14.5 (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl21a in Genome Data Viewer
    Location:
    1 C2; 1 32.74 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (64645632..64661926, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (64606473..64620466, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36148 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:64578558-64578769 Neighboring gene STARR-positive B cell enhancer ABC_E4317 Neighboring gene STARR-positive B cell enhancer ABC_E2546 Neighboring gene cAMP responsive element binding protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:64631759-64632060 Neighboring gene STARR-positive B cell enhancer ABC_E10013 Neighboring gene predicted gene 29152 Neighboring gene RIKEN cDNA 2810408I11 gene Neighboring gene STARR-positive B cell enhancer ABC_E983

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. METTL21A, a Non-Histone Methyltransferase, Is Dispensable for Spermatogenesis and Male Fertility in Mice. Li J, et al. Int J Mol Sci, 2022 Feb 9. PMID 35216057, Free PMC Article
    2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein N-lysine methyltransferase METTL21A
    Names
    family with sequence similarity 119, member A
    methyltransferase like 21A
    methyltransferase-like protein 21A
    protein-lysine methyltransferase METTL21A
    NP_001355212.1
    NP_001355213.1
    NP_080240.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368283.1 → NP_001355212.1  protein N-lysine methyltransferase METTL21A

      Status: VALIDATED

      Source sequence(s)
      AC166336
      Consensus CDS
      CCDS15006.1
      UniProtKB/Swiss-Prot
      Q8R2Y7, Q9CQL0

    2. NM_001368284.1 → NP_001355213.1  protein N-lysine methyltransferase METTL21A

      Status: VALIDATED

      Source sequence(s)
      AC166336
      Consensus CDS
      CCDS15006.1
      UniProtKB/Swiss-Prot
      Q8R2Y7, Q9CQL0
      Related
      ENSMUSP00000109713.3, ENSMUST00000114079.9

    3. NM_025964.4 → NP_080240.1  protein N-lysine methyltransferase METTL21A

      See identical proteins and their annotated locations for NP_080240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC166336
      Consensus CDS
      CCDS15006.1
      UniProtKB/Swiss-Prot
      Q8R2Y7, Q9CQL0
      Related
      ENSMUSP00000050424.2, ENSMUST00000053469.2
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 190
      Methyltransf_16; Lysine methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      64645632..64661926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001785519.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQL0.1 GenPept UniProtKB/Swiss-Prot:Q9CQL0

    Gene LinkOut

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