Fzd6 frizzled class receptor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fzd6provided by MGI
Official Full Name: frizzled class receptor 6provided by MGI
Primary source: MGI:MGI:108474
See related: Ensembl:ENSMUSG00000022297 AllianceGenome:MGI:108474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fz6; rst
Summary: Enables Wnt-protein binding activity. Acts upstream of or within several processes, including cell proliferation in midbrain; embryonic morphogenesis; and establishment of body hair planar orientation. Located in apical plasma membrane; apicolateral plasma membrane; and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 8.3), limb E14.5 (RPKM 5.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (38869673..38901587)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (39006149..39038192)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-199b-5p enhances the proliferation of medullary thymic epithelial cells via regulating Wnt signaling by targeting Fzd6.
Title: miR-199b-5p enhances the proliferation of medullary thymic epithelial cells via regulating Wnt signaling by targeting Fzd6.
Mesenchymal stem cell-derived extracellular vesicles suppress the fibroblast proliferation by downregulating FZD6 expression in fibroblasts via micrRNA-29b-3p in idiopathic pulmonary fibrosis.
Title: Mesenchymal stem cell-derived extracellular vesicles suppress the fibroblast proliferation by downregulating FZD6 expression in fibroblasts via micrRNA-29b-3p in idiopathic pulmonary fibrosis.
We demonstrate using mice that Fzd3 and Fzd6 similarly regulate axon turning, are functionally redundant with each other, and that Fzd3 genetically interacts with Vangl2 to guide this process
Title: Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons.
Fzd3 and Fzd6 play a redundant role in controlling the polarity of developing skin, but through non-identical mechanisms.
Title: Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.
Fzd4 and Fzd6 genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency
Title: Planar cell polarity genes frizzled4 and frizzled6 exert patterning influence on arterial vessel morphogenesis.
Eliminating Fz6 in most hair follicle cells or in the inter-follicular epidermis at E15.5 suggests that planar cell polarity signaling in developing follicles is not required to maintain their orientation.
Title: The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation.
Data show that Wnt receptor, Frizzled-6 (Fzd6) -/- hematopoietic stem/progenitor cell (HSPC) exhibit poor emergency hematopoiesis.
Title: Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal.
Fz3 and Fz6 have partly interchangeable roles in tissue polarity signaling for epithelial orientation and axon growth and guidance
Title: Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.
This study confirms our speculation that down-regulation of FZD6 by beta-Carotene is causally related to the observed up-regulation of cancer related genes
Title: Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung.
Fzd6-mediated Wnt signaling likely regulates the overall differentiation process of nail/claw formation.
Title: Frizzled6 deficiency disrupts the differentiation process of nail development.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Spontaneous (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fzd6 (e-PCR), detects polymorphism
- UniSTS:506912

NoName (e-PCR)
- UniSTS:225140

Fzd6 (e-PCR), detects polymorphism
- UniSTS:516479

U43319 (e-PCR)
- UniSTS:163554

NoName (e-PCR)
- UniSTS:548583

Fzd6 (e-PCR), detects polymorphism
- UniSTS:508391

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell proliferation in midbrain	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic nail plate morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of body hair planar orientation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: frizzled-6

Names: frizzled homolog 6; fz-6; mFz6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162494.1 → NP_001155966.1 frizzled-6 isoform 1 precursor

See identical proteins and their annotated locations for NP_001155966.1

Status: VALIDATED

Source sequence(s)

AC164883, AK138964, BB613669, BE648857, CD348842

Consensus CDS

CCDS27441.1

UniProtKB/Swiss-Prot

Q61089

UniProtKB/TrEMBL

Q542J1, Q8R382

Related

ENSMUSP00000136328.2, ENSMUST00000179165.9

Conserved Domains (2) summary

cd07450
Location:20 → 146

CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor

cd15032
Location:188 → 508

7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors
NM_001411226.1 → NP_001398155.1 frizzled-6 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC164883

UniProtKB/Swiss-Prot

Q61089

UniProtKB/TrEMBL

Q542J1
NM_001411227.1 → NP_001398156.1 frizzled-6 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC164883
NM_008056.4 → NP_032082.3 frizzled-6 isoform 1 precursor

See identical proteins and their annotated locations for NP_032082.3

Status: VALIDATED

Source sequence(s)

AC164883

Consensus CDS

CCDS27441.1

UniProtKB/Swiss-Prot

Q61089

UniProtKB/TrEMBL

Q542J1, Q8R382

Related

ENSMUSP00000022906.8, ENSMUST00000022906.8

Conserved Domains (2) summary

cd07450
Location:20 → 146

CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor

cd15032
Location:188 → 508

7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

38869673..38901587

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159158.1 → XP_036015051.1 frizzled-6 isoform X4

Conserved Domains (2) summary

cd07450
Location:20 → 146

CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor

cd15032
Location:188 → 464

7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors
XM_006520438.4 → XP_006520501.1 frizzled-6 isoform X2

See identical proteins and their annotated locations for XP_006520501.1

UniProtKB/TrEMBL

Q8R382

Conserved Domains (2) summary

cd15032
Location:139 → 459

7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

cl02447
Location:8 → 97

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
XM_036159156.1 → XP_036015049.1 frizzled-6 isoform X1

UniProtKB/Swiss-Prot

Q61089

UniProtKB/TrEMBL

Q542J1, Q8R382

Conserved Domains (2) summary

cd07450
Location:20 → 146

CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor

cd15032
Location:188 → 508

7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors
XM_011245454.3 → XP_011243756.1 frizzled-6 isoform X2

See identical proteins and their annotated locations for XP_011243756.1

UniProtKB/TrEMBL

Q8R382

Conserved Domains (2) summary

cd15032
Location:139 → 459

7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

cl02447
Location:8 → 97

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain