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    Nipsnap1 nipsnap homolog 1 [ Mus musculus (house mouse) ]

    Gene ID: 18082, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nipsnap1provided by MGI
    Official Full Name
    nipsnap homolog 1provided by MGI
    Primary source
    MGI:MGI:1278344
    See related
    Ensembl:ENSMUSG00000034285 AllianceGenome:MGI:1278344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Involved in mitophagy and sensory perception of pain. Located in membrane and mitochondrion. Is active in synaptic membrane. Is expressed in several structures, including gonad; gut; nervous system; submandibular gland primordium; and tooth. Orthologous to human NIPSNAP1 (nipsnap homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 20.7), kidney adult (RPKM 12.3) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nipsnap1 in Genome Data Viewer
    Location:
    11 A1; 11 3.07 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4823951..4844201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4873951..4894201)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neurofibromin 2 Neighboring gene STARR-seq mESC enhancer starr_28406 Neighboring gene STARR-seq mESC enhancer starr_28409 Neighboring gene STARR-seq mESC enhancer starr_28411 Neighboring gene STARR-seq mESC enhancer starr_28412 Neighboring gene peptidase M20 domain containing 2 pseudogene Neighboring gene microRNA 6918 Neighboring gene THO complex 5 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 35321 Neighboring gene neurofilament, heavy polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nipsnap1-A regulatory factor required for long-term maintenance of non-shivering thermogenesis. Liu Y, et al. Mol Metab, 2023 Sep. PMID 37423391, Free PMC Article
    2. Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity. Schoeber JP, et al. Pflugers Arch, 2008 Oct. PMID 18392847
    3. Human and mouse ABCA1 comparative sequencing and transgenesis studies revealing novel regulatory sequences. Qiu Y, et al. Genomics, 2001 Apr 1. PMID 11352567
    4. Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family. Tummala H, et al. Eur J Neurosci, 2010 Jun. PMID 20497468
    5. Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission. Okuda-Ashitaka E, et al. J Biol Chem, 2012 Mar 23. PMID 22311985, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NIPSNAP1 is an interacting molecule of NST and plays a crucial role in pain transmission.
      Title: Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission.
    2. This study presents the first physiological function of Nipsnap1 as an associated protein inhibiting transient receptor potential vanilloid channel 6 activity that possibly exerts its effect directly at the plasma membrane.
      Title: Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity.
    3. Data suggest that amyloid precursor proteins may affect mitochondrial function through a direct interaction with NIPSNAP1 as well as with other mitochondrial proteins.
      Title: Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein NipSnap homolog 1
    Names
    4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008698.3 → NP_032724.1  protein NipSnap homolog 1

      Status: VALIDATED

      Source sequence(s)
      AK013140, AK031804, BP771057, BY712531
      Consensus CDS
      CCDS24392.1
      UniProtKB/Swiss-Prot
      O55125
      UniProtKB/TrEMBL
      Q5SVF7
      Related
      ENSMUSP00000049338.3, ENSMUST00000038570.9
      Conserved Domains (1) summary
      pfam07978
      Location:185 → 282
      NIPSNAP; NIPSNAP

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4823951..4844201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514575.5 → XP_006514638.1  protein NipSnap homolog 1 isoform X1

      UniProtKB/TrEMBL
      Q3UGS1
      Conserved Domains (1) summary
      pfam07978
      Location:188 → 285
      NIPSNAP

    2. XM_006514577.3 → XP_006514640.1  protein NipSnap homolog 1 isoform X2

      Conserved Domains (1) summary
      pfam07978
      Location:61 → 158
      NIPSNAP

    RNA

    1. XR_001779913.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55125.1 GenPept UniProtKB/Swiss-Prot:O55125

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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