Dpysl3 dihydropyrimidinase-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpysl3provided by MGI
Official Full Name: dihydropyrimidinase-like 3provided by MGI
Primary source: MGI:MGI:1349762
See related: Ensembl:ENSMUSG00000024501 AllianceGenome:MGI:1349762
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TUC4; Ulip; DRP-3; Ulip1; CRMP-4; ULIP-1
Summary: This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Expression: Biased expression in CNS E18 (RPKM 272.7), whole brain E14.5 (RPKM 195.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18; 18 B3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (43454044..43571354, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (43320979..43438286, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of CRMP4 in LPS-induced neuroinflammation.
Title: The role of CRMP4 in LPS-induced neuroinflammation.
CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice.
Title: CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice.
CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
Title: CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.
Title: A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.
Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury.
Title: Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury.
Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.
Title: Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.
Results found that Crmp4-KO mice have abnormalities that are relevant to some phenotypes of human autism spectrum disorders (ASD). Accumulating evidence suggests that a disturbance in the regulatory function of CRMP4 in forming neuronal networks is an important aspect underlying some characteristics of ASD, including sexual differences. These findings provide CRMP4 as a novel candidate gene contributing to ASD.
Title: Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
Knockdown of DPYSL3 promoted the metastatic ability of Lewis lung carcinoma cells.
Title: Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer.
findings identify CRMP4 as a novel negative regulator of osteoblast differentiation.
Title: CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling.
Crmp4 deletion promotes axonal growth and nociceptive recovery after spinal cord injury.
Title: Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Mit202 (e-PCR), detects polymorphism
- UniSTS:128221

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables chondroitin sulfate binding	ISO Inferred from Sequence Orthology more info
enables chondroitin sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables filamin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin crosslink formation	ISO Inferred from Sequence Orthology more info
involved_in actin crosslink formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cytokine stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to axon injury	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
colocalizes_with exocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dihydropyrimidinase-related protein 3

Names: collapsin response mediator protein 4; unc-33-like phosphoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136086.2 → NP_001129558.1 dihydropyrimidinase-related protein 3 isoform 1

See identical proteins and their annotated locations for NP_001129558.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than CRMP4b.

Source sequence(s)

AC101718, AK133040, BQ175584

Consensus CDS

CCDS50269.1

UniProtKB/TrEMBL

Q3TT92

Related

ENSMUSP00000113711.2, ENSMUST00000118043.8

Conserved Domains (2) summary

PRK09060
Location:15 → 465

PRK09060; dihydroorotase; Validated

TIGR02033
Location:15 → 469

D-hydantoinase; D-hydantoinase
NM_001291455.2 → NP_001278384.1 dihydropyrimidinase-related protein 3 isoform CRMP4b

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (CRMP4b, also known as isoform 3).

Source sequence(s)

AC101718

Consensus CDS

CCDS79639.1

UniProtKB/TrEMBL

E9PWE8

Related

ENSMUSP00000112928.2, ENSMUST00000121805.9

Conserved Domains (2) summary

PRK09060
Location:130 → 580

PRK09060; dihydroorotase; Validated

TIGR02033
Location:130 → 584

D-hydantoinase; D-hydantoinase
NM_009468.6 → NP_033494.1 dihydropyrimidinase-related protein 3 isoform CRMP4a

See identical proteins and their annotated locations for NP_033494.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (CRMP4a, also known as isoform 2) has a distinct N-terminus and is shorter than CRMP4b.

Source sequence(s)

AC101718

Consensus CDS

CCDS37801.1

UniProtKB/Swiss-Prot

Q62188

Related

ENSMUSP00000025379.8, ENSMUST00000025379.14

Conserved Domains (2) summary

PRK09060
Location:17 → 467

PRK09060; dihydroorotase; Validated

TIGR02033
Location:17 → 471

D-hydantoinase; D-hydantoinase