Eea1 early endosome antigen 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eea1provided by MGI
Official Full Name: early endosome antigen 1provided by MGI
Primary source: MGI:MGI:2442192
See related: Ensembl:ENSMUSG00000036499 AllianceGenome:MGI:2442192
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZFYVE2; A430109M19Rik; B230358H09Rik
Summary: Predicted to enable 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Involved in chemical postsynaptic transmission. Located in axonal spine and early endosome. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic early endosome. Is expressed in several structures, including central nervous system; genitourinary system; heart; pancreatic acinus; and yolk sac. Orthologous to human EEA1 (early endosome antigen 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 5.5), placenta adult (RPKM 5.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C2; 10 49.59 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (95776525..95881380)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (95940663..96045518)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early endosome autoantigen 1 regulates IL-1beta release upon caspase-1 activation independently of gasdermin D membrane permeabilization.
Title: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization.
larger autophagic vacuoles that colocalize with early endosome antigen 1 (EEA1) but not with lysosomal-associated membrane protein (LAMP)-1 were much more frequently formed in Rab7(Deltapan) pancreatic acinar cells.
Title: Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models.
Our characterization of the role of EEA1 during homeostatic synaptic plasticity in Mecp2 KO neurons provides potentially novel targets of intervention for improving hippocampal function in Rett Syndrome individuals.
Title: EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice.
In the present study, decreased expression of EEA1 as well as the rearrangement of the actin was observed when Paracoccidioides brasiliensis was internalized in macrophages.
Title: Early Endosome Antigen 1 (EEA1) decreases in macrophages infected with Paracoccidioides brasiliensis.
F. tularensis-containing endosomes associated with early endosome antigen 1 (EEA1) followed by lysosome-associated membrane protein 1 (LAMP-1), with peak coassociation frequencies occurring at 30 and 120 min postinoculation, respectively.
Title: Francisella tularensis invasion of lung epithelial cells.
Tec vesicles have a membrane proximal location and overlap with the tyrosine kinase Lck, the Tec substrate PLC-gamma1, and the early endosomal antigen 1 marker EEA1
Title: Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy.
phosphomimetic mutation of Thr-1392 in EEA1 can bypass the requirement for p38alpha in mu opioid receptor endocytosis
Title: Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

31.MMHAP28FRC10.seq (e-PCR)
- UniSTS:123937

RH130537 (e-PCR)
- UniSTS:213821

D9S55 (e-PCR)
- UniSTS:146823

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission, postsynaptic	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in modulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in vesicle fusion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axonal spine	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: early endosome antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001932.3 → NP_001001932.1 early endosome antigen 1

See identical proteins and their annotated locations for NP_001001932.1

Status: VALIDATED

Source sequence(s)

AC115970, BB638838, BC075637

Consensus CDS

CCDS36042.1

UniProtKB/Swiss-Prot

Q6DIC2, Q8BL66

Related

ENSMUSP00000061493.7, ENSMUST00000053484.8

Conserved Domains (3) summary

cd15730
Location:1347 → 1409

FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins

pfam01576
Location:107 → 1119

Myosin_tail_1; Myosin tail

pfam07851
Location:909 → 988

TMPIT; TMPIT-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

95776525..95881380

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513522.5 → XP_006513585.1 early endosome antigen 1 isoform X1

Conserved Domains (3) summary

COG1196
Location:504 → 1346

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:130 → 794

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd15730
Location:1394 → 1456

FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
XM_006513523.5 → XP_006513586.1 early endosome antigen 1 isoform X2

Conserved Domains (3) summary

COG1196
Location:499 → 1341

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:130 → 789

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd15730
Location:1389 → 1451

FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
XM_006513524.5 → XP_006513587.1 early endosome antigen 1 isoform X3

Conserved Domains (3) summary

COG1196
Location:462 → 1304

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:88 → 752

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd15730
Location:1352 → 1414

FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
XM_006513525.5 → XP_006513588.1 early endosome antigen 1 isoform X4

Conserved Domains (3) summary

COG1196
Location:342 → 1184

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:19 → 622

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd15730
Location:1232 → 1294

FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins