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    Phtf2 putative homeodomain transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 68770, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Phtf2provided by MGI
    Official Full Name
    putative homeodomain transcription factor 2provided by MGI
    Primary source
    MGI:MGI:1916020
    See related
    Ensembl:ENSMUSG00000039987 AllianceGenome:MGI:1916020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110054G21Rik; 9530062N20Rik
    Summary
    Predicted to be located in endoplasmic reticulum. Is expressed in brain. Orthologous to human PHTF2 (putative homeodomain transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart adult (RPKM 6.9), CNS E18 (RPKM 5.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phtf2 in Genome Data Viewer
    Location:
    5 A3; 5 9.83 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (20963662..21087122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (20758664..20882137, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene membrane associated guanylate kinase, WW and PDZ domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_12541 Neighboring gene STARR-seq mESC enhancer starr_12543 Neighboring gene STARR-seq mESC enhancer starr_12544 Neighboring gene STARR-seq mESC enhancer starr_12546 Neighboring gene STARR-seq mESC enhancer starr_12547 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12550 Neighboring gene predicted gene, 52763 Neighboring gene STARR-seq mESC enhancer starr_12553 Neighboring gene ribosomal protein L31, pseudogene 5 Neighboring gene STARR-positive B cell enhancer ABC_E1675 Neighboring gene predicted gene, 52806 Neighboring gene RIKEN cDNA A630072M18 gene Neighboring gene STARR-seq mESC enhancer starr_12554 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:20447096-20447297 Neighboring gene STARR-seq mESC enhancer starr_12555 Neighboring gene STARR-seq mESC enhancer starr_12556 Neighboring gene predicted gene, 42219 Neighboring gene transmembrane protein 60 Neighboring gene round spermatid basic protein 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein PHTF2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172992.3 → NP_766580.3  protein PHTF2

      See identical proteins and their annotated locations for NP_766580.3

      Status: VALIDATED

      Source sequence(s)
      AK004246, AK037021, AK042382, AK151762, CB245749
      Consensus CDS
      CCDS51426.1
      UniProtKB/Swiss-Prot
      Q7TPX6, Q8CB19
      UniProtKB/TrEMBL
      A0A0R4J1Q1
      Related
      ENSMUSP00000114087.2, ENSMUST00000118174.8
      Conserved Domains (1) summary
      pfam12129
      Location:5 → 152
      Phtf-FEM1B_bdg; Male germ-cell putative homeodomain transcription factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      20963662..21087122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535801.3 → XP_006535864.1  protein PHTF2 isoform X3

      UniProtKB/Swiss-Prot
      Q7TPX6, Q8CB19
      Conserved Domains (1) summary
      pfam12129
      Location:5 → 154
      Phtf-FEM1B_bdg; Male germ-cell putative homeodomain transcription factor

    2. XM_036165461.1 → XP_036021354.1  protein PHTF2 isoform X2

      UniProtKB/Swiss-Prot
      Q7TPX6, Q8CB19
      Conserved Domains (1) summary
      pfam12129
      Location:5 → 158
      Phtf-FEM1B_bdg; Male germ-cell putative homeodomain transcription factor

    3. XM_036165460.1 → XP_036021353.1  protein PHTF2 isoform X1

      UniProtKB/Swiss-Prot
      Q7TPX6, Q8CB19
      Conserved Domains (1) summary
      pfam12129
      Location:5 → 158
      Phtf-FEM1B_bdg; Male germ-cell putative homeodomain transcription factor

    4. XM_030254785.2 → XP_030110645.1  protein PHTF2 isoform X6

    5. XM_036165462.1 → XP_036021355.1  protein PHTF2 isoform X4

      UniProtKB/Swiss-Prot
      Q7TPX6, Q8CB19
      Conserved Domains (1) summary
      pfam12129
      Location:1 → 17
      Phtf-FEM1B_bdg; Male germ-cell putative homeodomain transcription factor

    6. XM_036165463.1 → XP_036021356.1  protein PHTF2 isoform X4

      UniProtKB/Swiss-Prot
      Q7TPX6, Q8CB19
      Conserved Domains (1) summary
      pfam12129
      Location:1 → 17
      Phtf-FEM1B_bdg; Male germ-cell putative homeodomain transcription factor

    7. XM_036165465.1 → XP_036021358.1  protein PHTF2 isoform X6

    8. XM_036165464.1 → XP_036021357.1  protein PHTF2 isoform X5

      Conserved Domains (1) summary
      pfam12129
      Location:5 → 154
      Phtf-FEM1B_bdg; Male germ-cell putative homeodomain transcription factor

    RNA

    1. XR_003955706.2 RNA Sequence

    2. XR_004942555.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CB19.2 GenPept UniProtKB/Swiss-Prot:Q8CB19

    Gene LinkOut

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