Tmt1a thiol methyltransferase 1A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmt1aprovided by MGI
Official Full Name: thiol methyltransferase 1A1provided by MGI
Primary source: MGI:MGI:1916523
See related: Ensembl:ENSMUSG00000054619 AllianceGenome:MGI:1916523
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aam-B; UbiE1; Mettl7a; Mettl7a1; 2210414H16Rik; 3300001H21Rik
Summary: Predicted to enable mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Predicted to be involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 144.1), kidney adult (RPKM 109.2) and 14 other tissues See more
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Genomic context

Location:: 15 F1; 15 56.25 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (100201969..100227882)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (100304145..100330001)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA EPR-induced METTL7A1 modulates target gene translation.
Title: LncRNA EPR-induced METTL7A1 modulates target gene translation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables mRNA m(6)A methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiol S-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lncRNA processing	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: methyltransferase-like protein 7A

Names: methyltransferase like 7A; methyltransferase like 7A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027334.3 → NP_081610.2 methyltransferase-like protein 7A

See identical proteins and their annotated locations for NP_081610.2

Status: PROVISIONAL

Source sequence(s)

AK076169

Consensus CDS

CCDS27833.1

UniProtKB/TrEMBL

Q5K4Q9, Q8C6B0

Related

ENSMUSP00000065271.4, ENSMUST00000067752.5

Conserved Domains (2) summary

COG0500
Location:70 → 187

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam08241
Location:75 → 172

Methyltransf_11; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

100201969..100227882

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521389.2 → XP_006521452.1 methyltransferase-like protein 7A isoform X1

UniProtKB/TrEMBL

Q5K4Q9

Related

ENSMUSP00000155621.2, ENSMUST00000230472.2

Conserved Domains (1) summary

pfam08241
Location:57 → 154

Methyltransf_11; Methyltransferase domain
XM_006521390.5 → XP_006521453.1 methyltransferase-like protein 7A isoform X3

UniProtKB/TrEMBL

Q76I24

Conserved Domains (1) summary

pfam08241
Location:30 → 127

Methyltransf_11; Methyltransferase domain
XM_011245728.2 → XP_011244030.1 methyltransferase-like protein 7A isoform X2

See identical proteins and their annotated locations for XP_011244030.1

UniProtKB/TrEMBL

H3BJI7, Q9D7S5

Related

ENSMUSP00000155112.2, ENSMUST00000229588.2

Conserved Domains (1) summary

pfam08241
Location:75 → 166

Methyltransf_11; Methyltransferase domain