Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnj9provided by MGI
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 9provided by MGI
Primary source: MGI:MGI:108007
See related: Ensembl:ENSMUSG00000038026 AllianceGenome:MGI:108007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Girk3; Kir3.3; mbGIRK3; 1700085N21Rik
Summary: Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Involved in regulation of presynaptic membrane potential. Is active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in central nervous system; eye; intestine; and male reproductive gland or organ. Orthologous to human KCNJ9 (potassium inwardly rectifying channel subfamily J member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 37.4), cerebellum adult (RPKM 26.5) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.66 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (172148075..172156889, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172320508..172329322, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GIRK-3 knock-out mice show significant ethanol conditioned place preference and reward compared to wild-type littermates.
Title: G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward.
GIRK3 appears to be a critical gatekeeper of ethanol incentive salience and a potential target for the treatment of excessive ethanol consumption.
Title: GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.
a decisive role for the neuronal K(+) channel in regulating NCAM-dependent neurite outgrowth and attribute a physiologically meaningful role to the functional interplay of Kir3.3, NCAM, and TrkB in ontogeny
Title: Functional consequences of the interactions among the neural cell adhesion molecule NCAM, the receptor tyrosine kinase TrkB, and the inwardly rectifying K+ channel KIR3.3.
Kcnj9 as a particularly promising candidate and report the development of a Kcnj9-null mutant model that exhibits significantly less severe withdrawal from pentobarbital as well as other sedative-hypnotics.
Title: Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.
GIRK channels make important contribution to a range of behaviors and may represent points of therapeutic intervention in disorders of anxiety, spasticity and reward
Title: Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.
Results describe opioid-induced postsynaptic inhibition in locus coeruleus neurons from wild-type and GIRK2/GIRK3(-/-) mice at baseline and following chronic morphine treatment.
Title: Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK-knockout mice.
Inhibition of adrenergic tone is required for the induction of dependence, and channels containing GIRK2 and GIRK3 serve as inhibitory gate.
Title: Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.
GIRK3 exhibited in Purkinje neurons, basket cells, stellate cells and unipolar brush cells.
Title: Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum.
A single locus is partially responsible for the genetic mediation of pain inhibition, and genetic variation associated with the potassium channel gene, Kcnj9, is a prime candidate for explaining the variable response to these analgesic drugs.
Title: Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcnj9 (e-PCR), detects polymorphism
- UniSTS:143668

Kcnj9 (e-PCR), detects polymorphism
- UniSTS:143669

G42052 (e-PCR)
- UniSTS:105077

Kcnj9 (e-PCR), detects polymorphism
- UniSTS:498314

U11860 (e-PCR)
- UniSTS:158890

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to G-protein activated inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: G protein-activated inward rectifier potassium channel 3

Names: GIRK-3; inward rectifier K(+) channel Kir3.3; inwardly rectifier K(+) channel Kir3.3; potassium channel, inwardly rectifying subfamily J member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360808.1 → NP_001347737.1 G protein-activated inward rectifier potassium channel 3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC074311, AK046084, BC038600, BY128973

Consensus CDS

CCDS35783.1

UniProtKB/Swiss-Prot

P48543, Q9WUE1

UniProtKB/TrEMBL

Q544N3

Related

ENSMUSP00000141633.2, ENSMUST00000194204.2

Conserved Domains (2) summary

pfam01007
Location:25 → 164

IRK; Inward rectifier potassium channel

pfam17655
Location:171 → 334

IRK_C; Inward rectifier potassium channel C-terminal domain
NM_008429.3 → NP_032455.2 G protein-activated inward rectifier potassium channel 3

See identical proteins and their annotated locations for NP_032455.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK033970, BC038600, BY128973

Consensus CDS

CCDS35783.1

UniProtKB/Swiss-Prot

P48543, Q9WUE1

UniProtKB/TrEMBL

Q544N3

Related

ENSMUSP00000060110.3, ENSMUST00000062387.8

Conserved Domains (2) summary

pfam01007
Location:25 → 164

IRK; Inward rectifier potassium channel

pfam17655
Location:171 → 334

IRK_C; Inward rectifier potassium channel C-terminal domain