Aste1 asteroid homolog 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aste1provided by MGI
Official Full Name: asteroid homolog 1provided by MGI
Primary source: MGI:MGI:1913845
See related: Ensembl:ENSMUSG00000032567 AllianceGenome:MGI:1913845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1100001A21Rik
Summary: Predicted to enable 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in double-strand break repair via homologous recombination and double-strand break repair via nonhomologous end joining. Is expressed in brain. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to human ASTE1 (asteroid homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 4.8), limb E14.5 (RPKM 0.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 56.61 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (105272533..105285497)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (105395294..105408299)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

AV006403 (e-PCR)
- UniSTS:164416

Aste1 (e-PCR), detects polymorphism
- UniSTS:547424

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3' overhang single-stranded DNA endodeoxyribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info
enables single-stranded DNA endodeoxyribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: single-strand DNA endonuclease ASTE1; protein asteroid homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164828.1 → NP_001158300.1 single-strand DNA endonuclease ASTE1 isoform 2

See identical proteins and their annotated locations for NP_001158300.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC113016, AK006153

Consensus CDS

CCDS52905.1

UniProtKB/TrEMBL

E9Q1A4

Related

ENSMUSP00000131164.2, ENSMUST00000167674.2
NM_001357902.1 → NP_001344831.1 single-strand DNA endonuclease ASTE1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate segment compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC113016, BC098471, CJ226565

Consensus CDS

CCDS90653.1

Related

ENSMUSP00000149596.2, ENSMUST00000123807.8
NM_025651.5 → NP_079927.2 single-strand DNA endonuclease ASTE1 isoform 1

See identical proteins and their annotated locations for NP_079927.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC113016, AK030661

Consensus CDS

CCDS23465.1

UniProtKB/Swiss-Prot

Q4KMN1, Q80VC2, Q8BIR2

Related

ENSMUSP00000035181.4, ENSMUST00000035181.10

Conserved Domains (1) summary

cl28905
Location:28 → 181

PIN_SF; PIN (PilT N terminus) domain: Superfamily

RNA

NR_152139.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC113016