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    Ikbip IKBKB interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 67454, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ikbipprovided by MGI
    Official Full Name
    IKBKB interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1914704
    See related
    Ensembl:ENSMUSG00000019975 AllianceGenome:MGI:1914704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ikip; 1200009F10Rik; 1700023M03Rik
    Summary
    Predicted to be located in endoplasmic reticulum and nucleolus. Is expressed in mandible; maxilla; and rib. Orthologous to human IKBIP (IKBKB interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.6), limb E14.5 (RPKM 5.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ikbip in Genome Data Viewer
    Location:
    10 C2; 10 45.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (90918667..90938475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (91082737..91102613)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1B Neighboring gene STARR-seq mESC enhancer starr_27538 Neighboring gene predicted gene, 53598 Neighboring gene STARR-positive B cell enhancer ABC_E9131 Neighboring gene predicted gene, 25390 Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E370 Neighboring gene STARR-positive B cell enhancer ABC_E6900 Neighboring gene STARR-positive B cell enhancer ABC_E5165 Neighboring gene STARR-seq mESC enhancer starr_27543 Neighboring gene STARR-seq mESC enhancer starr_27545 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 Neighboring gene predicted gene, 24119 Neighboring gene nuclear encoded tRNA trytophan 2 (anticodon CCA) Neighboring gene thymopoietin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IKIP Negatively Regulates NF-κB Activation and Inflammation through Inhibition of IKKα/β Phosphorylation. Wu H, et al. J Immunol, 2020 Jan 15. PMID 31826938
    2. A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. Hofer-Warbinek R, et al. Cell Death Differ, 2004 Dec. PMID 15389287
    3. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of nuclear factor kappa-B kinase-interacting protein
    Names
    IKK-interacting protein
    i kappa-B kinase-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429495.1 → NP_001416424.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140410

    2. NM_026166.3 → NP_080442.2  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC140410
      Consensus CDS
      CCDS36031.1
      UniProtKB/Swiss-Prot
      Q7TMH1, Q8K1Z4, Q9DA09, Q9DBZ1
      UniProtKB/TrEMBL
      E9QMH7
      Related
      ENSMUSP00000020149.6, ENSMUST00000020149.6
      Conserved Domains (1) summary
      COG1196
      Location:64 → 349
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_027078.3 → NP_081354.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_081354.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' terminal exon, which results in a distinct 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC140410
      Consensus CDS
      CCDS24119.1
      UniProtKB/Swiss-Prot
      Q9DBZ1
      Related
      ENSMUSP00000020150.4, ENSMUST00000020150.10
      Conserved Domains (1) summary
      COG1196
      Location:71 → 342
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. NR_190741.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140410

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      90918667..90938475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314068.3 → XP_017169557.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      Q7TMH1, Q8K1Z4, Q9DA09, Q9DBZ1
      Conserved Domains (1) summary
      COG1196
      Location:59 → 326
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_001779582.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBZ1.2 GenPept UniProtKB/Swiss-Prot:Q9DBZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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