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    Lrrc51 leucine rich repeat containing 51 [ Mus musculus (house mouse) ]

    Gene ID: 69358, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc51provided by MGI
    Official Full Name
    leucine rich repeat containing 51provided by MGI
    Primary source
    MGI:MGI:1916608
    See related
    Ensembl:ENSMUSG00000064307 AllianceGenome:MGI:1916608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrtomt; 1700008D07Rik
    Summary
    Predicted to be located in cytoplasm. Is expressed in brain; gut gland; nasal cavity respiratory epithelium; respiratory system; and testis. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to human LRRC51 (leucine rich repeat containing 51); LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing); and TOMT (transmembrane O-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 271.1) and genital fat pad adult (RPKM 12.3) See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc51 in Genome Data Viewer
    Location:
    7 E2; 7 54.69 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101562196..101583126, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101912989..101933918, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex C subunit 15 Neighboring gene STARR-positive B cell enhancer ABC_E2837 Neighboring gene STARR-positive B cell enhancer ABC_E1350 Neighboring gene STARR-positive B cell enhancer ABC_E1089 Neighboring gene transmembrane O-methyltransferase Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene STARR-positive B cell enhancer ABC_E554 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8193 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans. Ahmed ZM, et al. Nat Genet, 2008 Nov. PMID 18953341, Free PMC Article
    2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 51
    NP_001156445.1
    NP_001156446.1
    NP_001344513.1
    NP_081329.1
    XP_006508246.1
    XP_011240195.1
    XP_011240196.1
    XP_011240197.1
    XP_011240198.1
    XP_030098830.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162973.2 → NP_001156445.1  leucine-rich repeat-containing protein 51 isoform 1

      See identical proteins and their annotated locations for NP_001156445.1

      Status: VALIDATED

      Source sequence(s)
      AC167240
      Consensus CDS
      CCDS52332.1
      UniProtKB/Swiss-Prot
      B6CZ58, B6CZ59, Q8R171, Q9DAK8
      UniProtKB/TrEMBL
      G5E8I1
      Related
      ENSMUSP00000102579.2, ENSMUST00000106966.8
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:89 → 173
      LRR_9; Leucine-rich repeat

    2. NM_001162974.3 → NP_001156446.1  leucine-rich repeat-containing protein 51 isoform 2

      See identical proteins and their annotated locations for NP_001156446.1

      Status: VALIDATED

      Source sequence(s)
      AC167240
      Consensus CDS
      CCDS52331.1
      UniProtKB/TrEMBL
      D3YVB2
      Related
      ENSMUSP00000102576.2, ENSMUST00000106963.2
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:85 → 146
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. NM_001357584.1 → NP_001344513.1  leucine-rich repeat-containing protein 51 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC167240
      Consensus CDS
      CCDS52332.1
      UniProtKB/Swiss-Prot
      B6CZ58, B6CZ59, Q8R171, Q9DAK8
      UniProtKB/TrEMBL
      G5E8I1
      Related
      ENSMUSP00000102581.2, ENSMUST00000106968.8
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:89 → 173
      LRR_9; Leucine-rich repeat

    4. NM_027053.2 → NP_081329.1  leucine-rich repeat-containing protein 51 isoform 1

      See identical proteins and their annotated locations for NP_081329.1

      Status: VALIDATED

      Source sequence(s)
      AC167240
      Consensus CDS
      CCDS52332.1
      UniProtKB/Swiss-Prot
      B6CZ58, B6CZ59, Q8R171, Q9DAK8
      UniProtKB/TrEMBL
      G5E8I1
      Related
      ENSMUSP00000077543.4, ENSMUST00000078448.11
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:89 → 173
      LRR_9; Leucine-rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101562196..101583126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508183.5 → XP_006508246.1  leucine-rich repeat-containing protein 51 isoform X1

      See identical proteins and their annotated locations for XP_006508246.1

      UniProtKB/Swiss-Prot
      B6CZ58, B6CZ59, Q8R171, Q9DAK8
      UniProtKB/TrEMBL
      G5E8I1
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:89 → 173
      LRR_9; Leucine-rich repeat

    2. XM_011241894.4 → XP_011240196.1  leucine-rich repeat-containing protein 51 isoform X1

      See identical proteins and their annotated locations for XP_011240196.1

      UniProtKB/Swiss-Prot
      B6CZ58, B6CZ59, Q8R171, Q9DAK8
      UniProtKB/TrEMBL
      G5E8I1
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:89 → 173
      LRR_9; Leucine-rich repeat

    3. XM_011241893.4 → XP_011240195.1  leucine-rich repeat-containing protein 51 isoform X1

      See identical proteins and their annotated locations for XP_011240195.1

      UniProtKB/Swiss-Prot
      B6CZ58, B6CZ59, Q8R171, Q9DAK8
      UniProtKB/TrEMBL
      G5E8I1
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:89 → 173
      LRR_9; Leucine-rich repeat

    4. XM_011241895.4 → XP_011240197.1  leucine-rich repeat-containing protein 51 isoform X1

      See identical proteins and their annotated locations for XP_011240197.1

      UniProtKB/Swiss-Prot
      B6CZ58, B6CZ59, Q8R171, Q9DAK8
      UniProtKB/TrEMBL
      G5E8I1
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:89 → 173
      LRR_9; Leucine-rich repeat

    5. XM_030242970.1 → XP_030098830.1  leucine-rich repeat-containing protein 51 isoform X2

      UniProtKB/TrEMBL
      D3YVB2
      Related
      ENSMUSP00000095838.3, ENSMUST00000098236.9
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:85 → 146
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    6. XM_011241896.2 → XP_011240198.1  leucine-rich repeat-containing protein 51 isoform X1

      See identical proteins and their annotated locations for XP_011240198.1

      UniProtKB/Swiss-Prot
      B6CZ58, B6CZ59, Q8R171, Q9DAK8
      UniProtKB/TrEMBL
      G5E8I1
      Conserved Domains (2) summary
      sd00033
      Location:52 → 80
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:89 → 173
      LRR_9; Leucine-rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAK8.1 GenPept UniProtKB/Swiss-Prot:Q9DAK8

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