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    Eef1d eukaryotic translation elongation factor 1 delta [ Mus musculus (house mouse) ]

    Gene ID: 66656, updated on 3-Dec-2024

    Summary

    Official Symbol
    Eef1dprovided by MGI
    Official Full Name
    eukaryotic translation elongation factor 1 deltaprovided by MGI
    Primary source
    MGI:MGI:1913906
    See related
    Ensembl:ENSMUSG00000055762 AllianceGenome:MGI:1913906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EF-1-delta
    Summary
    Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; guanyl-nucleotide exchange factor activity; and heat shock protein binding activity. Predicted to be involved in several processes, including cellular response to heat; cellular response to ionizing radiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 124.2), liver E14 (RPKM 58.1) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eef1d in Genome Data Viewer
    Location:
    15 D3; 15 35.05 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75766643..75781425, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75894796..75909784, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 6 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • 5730529A16Rik, 1700026P12Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    elongation factor 1-delta
    Names
    eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285429.2NP_001272358.1  elongation factor 1-delta isoform b

      See identical proteins and their annotated locations for NP_001272358.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.
      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS27554.1
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      UniProtKB/TrEMBL
      Q80T06
      Conserved Domains (1) summary
      pfam00736
      Location:198281
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    2. NM_001285430.2NP_001272359.1  elongation factor 1-delta isoform b

      See identical proteins and their annotated locations for NP_001272359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.
      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS27554.1
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      UniProtKB/TrEMBL
      Q80T06
      Related
      ENSMUSP00000023235.7, ENSMUST00000023235.13
      Conserved Domains (1) summary
      pfam00736
      Location:198281
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    3. NM_001285431.2NP_001272360.1  elongation factor 1-delta isoform c

      See identical proteins and their annotated locations for NP_001272360.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.
      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS70638.1
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      UniProtKB/TrEMBL
      A0A0R4J1L2
      Conserved Domains (1) summary
      pfam00736
      Location:174257
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    4. NM_001285432.2NP_001272361.1  elongation factor 1-delta isoform c

      See identical proteins and their annotated locations for NP_001272361.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.
      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS70638.1
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      UniProtKB/TrEMBL
      A0A0R4J1L2
      Related
      ENSMUSP00000105599.3, ENSMUST00000109972.9
      Conserved Domains (1) summary
      pfam00736
      Location:174257
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    5. NM_001285433.2NP_001272362.1  elongation factor 1-delta isoform c

      See identical proteins and their annotated locations for NP_001272362.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.
      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS70638.1
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      UniProtKB/TrEMBL
      A0A0R4J1L2
      Related
      ENSMUSP00000112141.3, ENSMUST00000116440.9
      Conserved Domains (1) summary
      pfam00736
      Location:174257
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    6. NM_001285434.2NP_001272363.1  elongation factor 1-delta isoform d

      See identical proteins and their annotated locations for NP_001272363.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter, compared to isoform a.
      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS70639.1
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      UniProtKB/TrEMBL
      Q91VK2
      Related
      ENSMUSP00000087109.4, ENSMUST00000089680.10
      Conserved Domains (1) summary
      pfam00736
      Location:193276
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    7. NM_001411966.1NP_001398895.1  elongation factor 1-delta isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, lacks portions of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
      Source sequence(s)
      AC116520
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    8. NM_001411967.1NP_001398896.1  elongation factor 1-delta isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, lacks portions of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
      Source sequence(s)
      AC116520
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    9. NM_001411968.1NP_001398897.1  elongation factor 1-delta isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, lacks portions of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
      Source sequence(s)
      AC116520
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    10. NM_001411969.1NP_001398898.1  elongation factor 1-delta isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.
      Source sequence(s)
      AC116520
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      UniProtKB/TrEMBL
      A0A0R4J1L2
    11. NM_001411970.1NP_001398899.1  elongation factor 1-delta isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.
      Source sequence(s)
      AC116520
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      UniProtKB/TrEMBL
      Q80T06
    12. NM_023240.4NP_075729.2  elongation factor 1-delta isoform b

      See identical proteins and their annotated locations for NP_075729.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.
      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS27554.1
      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      UniProtKB/TrEMBL
      Q80T06
      Related
      ENSMUSP00000116360.2, ENSMUST00000154584.9
      Conserved Domains (1) summary
      pfam00736
      Location:198281
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    13. NM_029663.3NP_083939.1  elongation factor 1-delta isoform a

      See identical proteins and their annotated locations for NP_083939.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS27553.1
      UniProtKB/TrEMBL
      A0A0R4J1E2, F6ZFU0
      Related
      ENSMUSP00000087110.6, ENSMUST00000089681.12
      Conserved Domains (1) summary
      pfam00736
      Location:577660
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75766643..75781425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521267.4XP_006521330.1  elongation factor 1-delta isoform X1

      See identical proteins and their annotated locations for XP_006521330.1

      UniProtKB/TrEMBL
      F6ZFU0
      Conserved Domains (2) summary
      pfam16471
      Location:478515
      JIP_LZII; JNK-interacting protein leucine zipper II
      pfam00736
      Location:596679
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    2. XM_036159544.1XP_036015437.1  elongation factor 1-delta isoform X5

      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      Conserved Domains (1) summary
      pfam00736
      Location:217300
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    3. XM_006521262.5XP_006521325.2  elongation factor 1-delta isoform X2

      UniProtKB/TrEMBL
      F6ZFU0
      Conserved Domains (2) summary
      pfam16471
      Location:477514
      JIP_LZII; JNK-interacting protein leucine zipper II
      pfam00736
      Location:595678
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    4. XM_006521265.5XP_006521328.2  elongation factor 1-delta isoform X4

      UniProtKB/TrEMBL
      F6ZFU0
      Related
      ENSMUSP00000114753.2, ENSMUST00000137426.8
      Conserved Domains (2) summary
      pfam16471
      Location:435472
      JIP_LZII; JNK-interacting protein leucine zipper II
      pfam00736
      Location:553636
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    5. XM_006521261.4XP_006521324.2  elongation factor 1-delta isoform X1

      See identical proteins and their annotated locations for XP_006521324.2

      UniProtKB/TrEMBL
      F6ZFU0
      Conserved Domains (2) summary
      pfam16471
      Location:478515
      JIP_LZII; JNK-interacting protein leucine zipper II
      pfam00736
      Location:596679
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    6. XM_006521264.5XP_006521327.2  elongation factor 1-delta isoform X3

      UniProtKB/TrEMBL
      F6ZFU0
      Conserved Domains (2) summary
      pfam16471
      Location:458495
      JIP_LZII; JNK-interacting protein leucine zipper II
      pfam00736
      Location:576659
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    7. XM_036159543.1XP_036015436.1  elongation factor 1-delta isoform X5

      UniProtKB/Swiss-Prot
      P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
      Conserved Domains (1) summary
      pfam00736
      Location:217300
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    8. XM_006521266.5XP_006521329.2  elongation factor 1-delta isoform X1

      See identical proteins and their annotated locations for XP_006521329.2

      UniProtKB/TrEMBL
      F6ZFU0
      Conserved Domains (2) summary
      pfam16471
      Location:478515
      JIP_LZII; JNK-interacting protein leucine zipper II
      pfam00736
      Location:596679
      EF1_GNE; EF-1 guanine nucleotide exchange domain