Smc4 structural maintenance of chromosomes 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smc4provided by MGI
Official Full Name: structural maintenance of chromosomes 4provided by MGI
Primary source: MGI:MGI:1917349
See related: Ensembl:ENSMUSG00000034349 AllianceGenome:MGI:1917349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SMC-4; Smc4l1; 2500002A22Rik
Summary: Enables chromatin binding activity and single-stranded DNA binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Acts upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Located in chromosome, centromeric region and condensed nuclear chromosome. Part of condensin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 30.9), CNS E11.5 (RPKM 28.6) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E1; 3 32.14 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (68912071..68941956)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (69004738..69034623)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural Maintenance of Chromosome Protein 4 Promotes the Progression of Cardia Adenocarcinoma via Regulation of the Wnt/beta-catenin Signaling Pathway.
Title: Structural Maintenance of Chromosome Protein 4 Promotes the Progression of Cardia Adenocarcinoma via Regulation of the Wnt/β-catenin Signaling Pathway.
TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.
Title: TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.
Study examined the expression of SMC4 in acute myeloid leukemia (AML) pediatric patients cells and normal cells and revealed that SMC4 was significantly higher than control. Utilizing SMC4 gene knockdown in the established MLL-AF9 AML mouse model study found that SMC4 knockdown inhibited AML progression by maintaining leukemia stem cells.
Title: Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126733 (e-PCR)
- UniSTS:207508

Zfp36 (e-PCR), detects polymorphism
- UniSTS:144829

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kinetochore organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in mitotic chromosome condensation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome condensation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in single strand break repair	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	ISO Inferred from Sequence Orthology more info
part_of condensin complex	NAS Non-traceable Author Statement more info	PubMed
part_of condensin complex	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: structural maintenance of chromosomes protein 4

Names: SMC protein 4; SMC4 structural maintenance of chromosomes 4-like 1; XCAP-C homolog; chromosome-associated polypeptide C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356976.1 → NP_001343905.1 structural maintenance of chromosomes protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC122876, BC062939

UniProtKB/TrEMBL

E9Q2X6, Q6P7V9

Conserved Domains (1) summary

pfam02463
Location:11 → 1202

SMC_N; RecF/RecN/SMC N terminal domain
NM_133786.4 → NP_598547.1 structural maintenance of chromosomes protein 4 isoform 1

See identical proteins and their annotated locations for NP_598547.1

Status: VALIDATED

Source sequence(s)

AC122876, BC062939, CN722683

Consensus CDS

CCDS17401.1

UniProtKB/Swiss-Prot

Q8BTS7, Q8BTY9, Q8CG47, Q99K21

UniProtKB/TrEMBL

E9Q2X6

Related

ENSMUSP00000047872.9, ENSMUST00000042901.15

Conserved Domains (1) summary

pfam02463
Location:81 → 1272

SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

68912071..68941956

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252813.2 → XP_030108673.1 structural maintenance of chromosomes protein 4 isoform X3

UniProtKB/TrEMBL

E9Q2X6

Conserved Domains (1) summary

COG1196
Location:11 → 1042

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006502046.3 → XP_006502109.1 structural maintenance of chromosomes protein 4 isoform X1

See identical proteins and their annotated locations for XP_006502109.1

UniProtKB/Swiss-Prot

Q8BTS7, Q8BTY9, Q8CG47, Q99K21

UniProtKB/TrEMBL

E9Q2X6

Conserved Domains (1) summary

pfam02463
Location:81 → 1272

SMC_N; RecF/RecN/SMC N terminal domain
XM_030252812.2 → XP_030108672.1 structural maintenance of chromosomes protein 4 isoform X2

UniProtKB/TrEMBL

E9Q2X6, Q6P7V9

Conserved Domains (1) summary

pfam02463
Location:11 → 1202

SMC_N; RecF/RecN/SMC N terminal domain
XM_036163300.1 → XP_036019193.1 structural maintenance of chromosomes protein 4 isoform X3

UniProtKB/TrEMBL

E9Q2X6

Conserved Domains (1) summary

COG1196
Location:11 → 1042

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_036163301.1 → XP_036019194.1 structural maintenance of chromosomes protein 4 isoform X3

UniProtKB/TrEMBL

E9Q2X6

Conserved Domains (1) summary

COG1196
Location:11 → 1042

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]