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    Far1 fatty acyl CoA reductase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67420, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Far1provided by MGI
    Official Full Name
    fatty acyl CoA reductase 1provided by MGI
    Primary source
    MGI:MGI:1914670
    See related
    Ensembl:ENSMUSG00000030759 AllianceGenome:MGI:1914670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlstd2; 2600011M19Rik; 2900034E22Rik; 3732409C05Rik
    Summary
    Enables alcohol-forming very long-chain fatty acyl-CoA reductase activity. Involved in wax biosynthetic process. Located in peroxisome. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctate type 4. Orthologous to human FAR1 (fatty acyl-CoA reductase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 22.8), CNS E18 (RPKM 14.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Far1 in Genome Data Viewer
    Location:
    7 F1; 7 59.21 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (113113008..113170713)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (113513719..113571506)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene parathyroid hormone Neighboring gene STARR-seq mESC enhancer starr_19909 Neighboring gene STARR-positive B cell enhancer mm9_chr7:120611773-120612073 Neighboring gene BCL2-associated transcription factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19911 Neighboring gene STARR-positive B cell enhancer ABC_E1355 Neighboring gene STARR-positive B cell enhancer ABC_E10465 Neighboring gene fatty acyl CoA reductase 1, opposite strand Neighboring gene predicted gene, 33828 Neighboring gene STARR-seq mESC enhancer starr_19913 Neighboring gene STARR-seq mESC enhancer starr_19915 Neighboring gene predicted gene, 39072

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disrupted intercellular bridges and spermatogenesis in fatty acyl-CoA reductase 1 knockout mice: A new model of ether lipid deficiency. Pan B, et al. FASEB J, 2023 May. PMID 37039784, Free PMC Article
    2. Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. Cheng JB, et al. J Biol Chem, 2004 Sep 3. PMID 15220348, Free PMC Article
    3. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. Cheng JB, et al. J Biol Chem, 2004 Sep 3. PMID 15220349, Free PMC Article
    4. CIN85 interacting proteins in B cells-specific role for SHIP-1. Büchse T, et al. Mol Cell Proteomics, 2011 Oct. PMID 21725061, Free PMC Article
    5. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes
      Title: Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family.
    2. fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids
      Title: Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ether lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ether lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycerophospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerophospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wax biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fatty acyl-CoA reductase 1
    Names
    male sterility domain containing 2
    NP_001272760.1
    NP_001347597.1
    NP_001347598.1
    NP_081655.2
    XP_006508192.1
    XP_006508193.1
    XP_006508194.1
    XP_030098792.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285831.2 → NP_001272760.1  fatty acyl-CoA reductase 1 isoform 2

      See identical proteins and their annotated locations for NP_001272760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the coding region compared to variant 1. The resulting isoform (2) is the same length and has the same N- and C-termini compared to isoform 1 but differs at an internal segment.
      Source sequence(s)
      AC102841, AC156987, AK033674
      Consensus CDS
      CCDS72024.1
      UniProtKB/Swiss-Prot
      Q922J9
      Related
      ENSMUSP00000064334.9, ENSMUST00000067929.15
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:371 → 447
      Sterile; Male sterility protein

    2. NM_001360668.1 → NP_001347597.1  fatty acyl-CoA reductase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC102841, AC156987
      Consensus CDS
      CCDS40093.1
      UniProtKB/Swiss-Prot
      Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
      Related
      ENSMUSP00000128695.2, ENSMUST00000164745.8
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    3. NM_001360669.1 → NP_001347598.1  fatty acyl-CoA reductase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC102841, AC156987
      Consensus CDS
      CCDS40093.1
      UniProtKB/Swiss-Prot
      Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    4. NM_027379.4 → NP_081655.2  fatty acyl-CoA reductase 1 isoform 1

      See identical proteins and their annotated locations for NP_081655.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC102841, AC156987, AK014486
      Consensus CDS
      CCDS40093.1
      UniProtKB/Swiss-Prot
      Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
      Related
      ENSMUSP00000033018.9, ENSMUST00000033018.15
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      113113008..113170713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242932.2 → XP_030098792.1  fatty acyl-CoA reductase 1 isoform X2

      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:371 → 447
      Sterile; Male sterility protein

    2. XM_006508130.4 → XP_006508193.1  fatty acyl-CoA reductase 1 isoform X1

      See identical proteins and their annotated locations for XP_006508193.1

      UniProtKB/Swiss-Prot
      Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    3. XM_006508129.4 → XP_006508192.1  fatty acyl-CoA reductase 1 isoform X1

      See identical proteins and their annotated locations for XP_006508192.1

      UniProtKB/Swiss-Prot
      Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    4. XM_006508131.4 → XP_006508194.1  fatty acyl-CoA reductase 1 isoform X1

      See identical proteins and their annotated locations for XP_006508194.1

      UniProtKB/Swiss-Prot
      Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026143.2: Suppressed sequence

      Description
      NM_026143.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922J9.1 GenPept UniProtKB/Swiss-Prot:Q922J9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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