Ppp1r16b protein phosphatase 1, regulatory subunit 16B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r16bprovided by MGI
Official Full Name: protein phosphatase 1, regulatory subunit 16Bprovided by MGI
Primary source: MGI:MGI:2151841
See related: Ensembl:ENSMUSG00000037754 AllianceGenome:MGI:2151841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdt4; TIMAP; ANKRD4; C130078N17Rik
Summary: Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Acts upstream of or within establishment of endothelial barrier. Predicted to be located in nuclear speck; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; eye; heart; hemolymphoid system; and spinal cord. Orthologous to human PPP1R16B (protein phosphatase 1 regulatory subunit 16B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 16.6), lung adult (RPKM 14.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 78.72 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (158508653..158608254)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (158666733..158766334)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIMAP is suppressed by TGFbeta via HDAC3-associated Smad signaling.
Title: TIMAP repression by TGFβ and HDAC3-associated Smad signaling regulates macrophage M2 phenotypic phagocytosis.
These data confirmed the barrier-protective role of TIMAP
Title: TIMAP protects endothelial barrier from LPS-induced vascular leakage and is down-regulated by LPS.
mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain.
Title: mPPP1R16B is a novel mouse protein phosphatase 1 targeting subunit whose mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables myosin phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in establishment of endothelial barrier	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of endothelial barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory inhibitor subunit 16B

Names: CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; protein phosphatase 1, regulatory (inhibitor) subunit 16B; whn-dependent transcript 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159662.1 → NP_001153134.1 protein phosphatase 1 regulatory inhibitor subunit 16B

See identical proteins and their annotated locations for NP_001153134.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

AK037627, AL663077, BY718617

Consensus CDS

CCDS16991.1

UniProtKB/Swiss-Prot

Q8VHQ3

UniProtKB/TrEMBL

A2AC90, Q544H9

Related

ENSMUSP00000039540.5, ENSMUST00000045503.11

Conserved Domains (3) summary

PHA03095
Location:71 → 301

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:71 → 98

ANK; ANK repeat [structural motif]

pfam12796
Location:72 → 164

Ank_2; Ankyrin repeats (3 copies)
NM_153089.4 → NP_694729.1 protein phosphatase 1 regulatory inhibitor subunit 16B

See identical proteins and their annotated locations for NP_694729.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AK037627, AL663077

Consensus CDS

CCDS16991.1

UniProtKB/Swiss-Prot

Q8VHQ3

UniProtKB/TrEMBL

A2AC90, Q544H9

Related

ENSMUSP00000099405.4, ENSMUST00000103116.10

Conserved Domains (3) summary

PHA03095
Location:71 → 301

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:71 → 98

ANK; ANK repeat [structural motif]

pfam12796
Location:72 → 164

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

158508653..158608254

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239493.3 → XP_011237795.1 protein phosphatase 1 regulatory inhibitor subunit 16B isoform X2

Conserved Domains (3) summary

PHA03095
Location:71 → 301

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:71 → 98

ANK; ANK repeat [structural motif]

pfam12796
Location:72 → 164

Ank_2; Ankyrin repeats (3 copies)
XM_011239492.4 → XP_011237794.1 protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

See identical proteins and their annotated locations for XP_011237794.1

UniProtKB/Swiss-Prot

Q8VHQ3

UniProtKB/TrEMBL

A2AC90, Q544H9

Related

ENSMUSP00000117310.2, ENSMUST00000145073.2

Conserved Domains (3) summary

PHA03095
Location:71 → 301

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:71 → 98

ANK; ANK repeat [structural motif]

pfam12796
Location:72 → 164

Ank_2; Ankyrin repeats (3 copies)