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    Caap1 caspase activity and apoptosis inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 67770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Caap1provided by MGI
    Official Full Name
    caspase activity and apoptosis inhibitor 1provided by MGI
    Primary source
    MGI:MGI:1915020
    See related
    Ensembl:ENSMUSG00000028578 AllianceGenome:MGI:1915020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAAP; 5830433M19Rik
    Summary
    Predicted to be involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Orthologous to human CAAP1 (caspase activity and apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.2), bladder adult (RPKM 2.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Caap1 in Genome Data Viewer
    Location:
    4 C5; 4 43.32 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94388318..94445033, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94500079..94556796, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12655 Neighboring gene STARR-seq mESC enhancer starr_10787 Neighboring gene STARR-seq mESC enhancer starr_10788 Neighboring gene predicted gene 12656 Neighboring gene phospholipase A2, activating protein Neighboring gene STARR-positive B cell enhancer ABC_E3497 Neighboring gene H3.5 histone Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Towards an understanding of C9orf82 protein/CAAP1 function. Aslam MA, et al. PLoS One, 2019. PMID 30629682, Free PMC Article
    2. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    3. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    caspase activity and apoptosis inhibitor 1
    Names
    conserved anti-apoptotic protein
    likely ortholog of H. sapiens chromosome 9 open reading frame 82 (C9orf82)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001406349.1 → NP_001393278.1  caspase activity and apoptosis inhibitor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL807252

    2. NM_001406350.1 → NP_001393279.1  caspase activity and apoptosis inhibitor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL807252

    3. NM_001406351.1 → NP_001393280.1  caspase activity and apoptosis inhibitor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL807252
      UniProtKB/TrEMBL
      Q3TUU0

    4. NM_026368.3 → NP_080644.2  caspase activity and apoptosis inhibitor 1 isoform 1

      See identical proteins and their annotated locations for NP_080644.2

      Status: VALIDATED

      Source sequence(s)
      AL807252
      Consensus CDS
      CCDS18358.1
      UniProtKB/Swiss-Prot
      Q3USG8, Q8VDY9
      UniProtKB/TrEMBL
      Q3TUU0
      Related
      ENSMUSP00000030313.9, ENSMUST00000030313.9
      Conserved Domains (1) summary
      pfam15335
      Location:114 → 175
      CAAP1; Caspase activity and apoptosis inhibitor 1

    RNA

    1. NR_176046.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL807252

    2. NR_176047.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL807252

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      94388318..94445033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDY9.2 GenPept UniProtKB/Swiss-Prot:Q8VDY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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