S100a4 S100 calcium binding protein A4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100a4provided by MGI
Official Full Name: S100 calcium binding protein A4provided by MGI
Primary source: MGI:MGI:1330282
See related: Ensembl:ENSMUSG00000001020 AllianceGenome:MGI:1330282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 42a; 18A2; Capl; FSp1; Mts1; pk9a; PeL98; metastasin
Summary: Enables calcium ion binding activity and identical protein binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in extracellular space; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; heart; and hemolymphoid system. Orthologous to human S100A4 (S100 calcium binding protein A4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 53.9), mammary gland adult (RPKM 13.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.27 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90511077..90513349)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90603770..90606045)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100A4 promotes experimental autoimmune encephalomyelitis by impacting microglial inflammation through TLR4/NF-kappaB signaling pathway.
Title: S100A4 promotes experimental autoimmune encephalomyelitis by impacting microglial inflammation through TLR4/NF-κB signaling pathway.
SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1.
Title: SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1.
TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.
Title: TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.
S100A4 Is a Key Facilitator of Thoracic Aortic Dissection.
Title: S100A4 Is a Key Facilitator of Thoracic Aortic Dissection.
METTL14 downregulation drives S100A4[+] monocyte-derived macrophages via MyD88/NF-kappaB pathway to promote MAFLD progression.
Title: METTL14 downregulation drives S100A4(+) monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression.
Inhibition of TLR4/NF-kappaB pathway and endoplasmic reticulum stress by overexpressed S100A4 ameliorates retinal ischemia-reperfusion injury of mice.
Title: Inhibition of TLR4/NF-κB pathway and endoplasmic reticulum stress by overexpressed S100A4 ameliorates retinal ischemia-reperfusion injury of mice.
A novel mechanoeffector role of fibroblast S100A4 in myofibroblast transdifferentiation and fibrosis.
Title: A novel mechanoeffector role of fibroblast S100A4 in myofibroblast transdifferentiation and fibrosis.
Secreted S100A4 causes asthmatic airway epithelial barrier dysfunction induced by house dust mite extracts via activating VEGFA/VEGFR2 pathway.
Title: Secreted S100A4 causes asthmatic airway epithelial barrier dysfunction induced by house dust mite extracts via activating VEGFA/VEGFR2 pathway.
S100A4-dependent glycolysis promotes lymphatic vessel sprouting in tumor.
Title: S100A4-dependent glycolysis promotes lymphatic vessel sprouting in tumor.
Notch Blockade Specifically in Bone Marrow-Derived FSP-1-Positive Cells Ameliorates Renal Fibrosis.
Title: Notch Blockade Specifically in Bone Marrow-Derived FSP-1-Positive Cells Ameliorates Renal Fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Dcr15 (e-PCR), detects polymorphism
- UniSTS:507665

S100a4 (e-PCR), detects polymorphism
- UniSTS:254235

S100a4 (e-PCR), detects polymorphism
- UniSTS:498484

D3Mit28 (e-PCR), detects polymorphism
- UniSTS:116288

D3Mit28.1 (e-PCR), detects polymorphism
- UniSTS:129708

D3Mit28.2 (e-PCR), detects polymorphism
- UniSTS:129709

S100a4 (e-PCR), detects polymorphism
- UniSTS:498402

S100a4 (e-PCR), detects polymorphism
- UniSTS:144367

D00208 (e-PCR)
- UniSTS:163320

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RAGE receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables RAGE receptor binding	IEA Inferred from Electronic Annotation more info
enables RAGE receptor binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A4

Names: Fibroblast-specific protein 1; calvasculin; metastatic cell protein; placental calcium-binding protein; protein 18A2; protein Mts1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410571.1 → NP_001397500.1 protein S100-A4

Status: VALIDATED

Source sequence(s)

AC160552

UniProtKB/Swiss-Prot

P07091, P20066

UniProtKB/TrEMBL

Q545V2
NM_001410572.1 → NP_001397501.1 protein S100-A4

Status: VALIDATED

Source sequence(s)

AC160552

UniProtKB/Swiss-Prot

P07091, P20066

UniProtKB/TrEMBL

Q545V2
NM_011311.3 → NP_035441.1 protein S100-A4

See identical proteins and their annotated locations for NP_035441.1

Status: VALIDATED

Source sequence(s)

AC160552

Consensus CDS

CCDS17538.1

UniProtKB/Swiss-Prot

P07091, P20066

UniProtKB/TrEMBL

Q545V2

Related

ENSMUSP00000001046.6, ENSMUST00000001046.7

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...