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    Anapc15 anaphase promoting complex C subunit 15 [ Mus musculus (house mouse) ]

    Gene ID: 75430, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Anapc15provided by MGI
    Official Full Name
    anaphase promoting complex C subunit 15provided by MGI
    Primary source
    MGI:MGI:1922680
    See related
    Ensembl:ENSMUSG00000030649 AllianceGenome:MGI:1922680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APC15; 3200002M19Rik; 6330414C15Rik
    Summary
    Predicted to be involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to be part of anaphase-promoting complex. Is expressed in several structures, including adrenal gland; brain; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ANAPC15 (anaphase promoting complex subunit 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.4), CNS E14 (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Anapc15 in Genome Data Viewer
    Location:
    7 E2; 7 54.68 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101530508..101551056)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101881300..101901849)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene folate receptor alpha Neighboring gene STARR-seq mESC enhancer starr_19700 Neighboring gene predicted gene, 35597 Neighboring gene STARR-positive B cell enhancer ABC_E2837 Neighboring gene STARR-positive B cell enhancer ABC_E1350 Neighboring gene STARR-positive B cell enhancer ABC_E1089 Neighboring gene transmembrane O-methyltransferase Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene leucine rich repeat containing 51 Neighboring gene STARR-positive B cell enhancer ABC_E554

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide screening reveals the genetic basis of mammalian embryonic eye development. Chee JM, et al. BMC Biol, 2023 Feb 3. PMID 36737727, Free PMC Article
    2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein branched polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 15
    Names
    anaphase prompoting complex C subunit 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291348.1 → NP_001278277.1  anaphase-promoting complex subunit 15 isoform a

      See identical proteins and their annotated locations for NP_001278277.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK135201, AK139635, CF166358
      Consensus CDS
      CCDS80760.1
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Conserved Domains (1) summary
      pfam15243
      Location:22 → 82
      ANAPC15; Anaphase-promoting complex subunit 15

    2. NM_001291349.1 → NP_001278278.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_001278278.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AK135201, BB636259, CF166358
      Consensus CDS
      CCDS80762.1
      UniProtKB/TrEMBL
      A0A1W2P6Q9, H3BIU1
      Related
      ENSMUSP00000102586.2, ENSMUST00000106973.8
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    3. NM_001291352.1 → NP_001278281.1  anaphase-promoting complex subunit 15 isoform c

      See identical proteins and their annotated locations for NP_001278281.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice junction at the 3' end of one exon and at the 5' end of the next exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
      Source sequence(s)
      AK135201, DV659149
      Consensus CDS
      CCDS21518.1
      UniProtKB/Swiss-Prot
      P60007, Q3UT90, Q3UXV5
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Related
      ENSMUSP00000147669.2, ENSMUST00000210984.2
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    4. NM_001291353.1 → NP_001278282.1  anaphase-promoting complex subunit 15 isoform c

      See identical proteins and their annotated locations for NP_001278282.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice junction at the 3' end of one exon and at the 5' end of the next exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
      Source sequence(s)
      AC167240, AK135201
      Consensus CDS
      CCDS21518.1
      UniProtKB/Swiss-Prot
      P60007, Q3UT90, Q3UXV5
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Related
      ENSMUSP00000102591.2, ENSMUST00000106978.8
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    5. NM_027532.4 → NP_081808.2  anaphase-promoting complex subunit 15 isoform c

      See identical proteins and their annotated locations for NP_081808.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of one exon and at the 5' end of the next exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
      Source sequence(s)
      AK135201, CF166358
      Consensus CDS
      CCDS21518.1
      UniProtKB/Swiss-Prot
      P60007, Q3UT90, Q3UXV5
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Related
      ENSMUSP00000114771.2, ENSMUST00000144207.9
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101530508..101551056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241930.2 → XP_011240232.1  anaphase-promoting complex subunit 15 isoform X1

      See identical proteins and their annotated locations for XP_011240232.1

      UniProtKB/TrEMBL
      G5E8M3
      Related
      ENSMUSP00000095839.3, ENSMUST00000098237.9
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    2. XM_036153505.1 → XP_036009398.1  anaphase-promoting complex subunit 15 isoform X1

      UniProtKB/TrEMBL
      G5E8M3
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    3. XM_011241935.4 → XP_011240237.1  anaphase-promoting complex subunit 15 isoform X4

      See identical proteins and their annotated locations for XP_011240237.1

      UniProtKB/TrEMBL
      A0A1W2P6Q9, H3BIU1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    4. XM_006508282.5 → XP_006508345.1  anaphase-promoting complex subunit 15 isoform X2

      See identical proteins and their annotated locations for XP_006508345.1

      UniProtKB/TrEMBL
      Q9D3A0
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    5. XM_006508285.5 → XP_006508348.1  anaphase-promoting complex subunit 15 isoform X2

      See identical proteins and their annotated locations for XP_006508348.1

      UniProtKB/TrEMBL
      Q9D3A0
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    6. XM_036153506.1 → XP_036009399.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      Q9D3A0
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    7. XM_006508280.5 → XP_006508343.1  anaphase-promoting complex subunit 15 isoform X1

      See identical proteins and their annotated locations for XP_006508343.1

      UniProtKB/TrEMBL
      G5E8M3
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    8. XM_036153514.1 → XP_036009407.1  anaphase-promoting complex subunit 15 isoform X4

      UniProtKB/TrEMBL
      A0A1W2P6Q9, H3BIU1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    9. XM_036153507.1 → XP_036009400.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      Q9D3A0
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    10. XM_006508284.5 → XP_006508347.1  anaphase-promoting complex subunit 15 isoform X2

      See identical proteins and their annotated locations for XP_006508347.1

      UniProtKB/TrEMBL
      Q9D3A0
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    11. XM_011241931.4 → XP_011240233.1  anaphase-promoting complex subunit 15 isoform X1

      See identical proteins and their annotated locations for XP_011240233.1

      UniProtKB/TrEMBL
      G5E8M3
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    12. XM_036153513.1 → XP_036009406.1  anaphase-promoting complex subunit 15 isoform X4

      UniProtKB/TrEMBL
      A0A1W2P6Q9, H3BIU1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    13. XM_030243050.2 → XP_030098910.1  anaphase-promoting complex subunit 15 isoform X3

      UniProtKB/Swiss-Prot
      P60007, Q3UT90, Q3UXV5
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    14. XM_036153512.1 → XP_036009405.1  anaphase-promoting complex subunit 15 isoform X4

      UniProtKB/TrEMBL
      A0A1W2P6Q9, H3BIU1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    15. XM_036153510.1 → XP_036009403.1  anaphase-promoting complex subunit 15 isoform X3

      UniProtKB/Swiss-Prot
      P60007, Q3UT90, Q3UXV5
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    16. XM_030243051.2 → XP_030098911.1  anaphase-promoting complex subunit 15 isoform X3

      UniProtKB/Swiss-Prot
      P60007, Q3UT90, Q3UXV5
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    17. XM_017312358.3 → XP_017167847.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      Q9D3A0
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    18. XM_030243052.2 → XP_030098912.1  anaphase-promoting complex subunit 15 isoform X3

      UniProtKB/Swiss-Prot
      P60007, Q3UT90, Q3UXV5
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Related
      ENSMUSP00000136164.2, ENSMUST00000178851.2
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    19. XM_011241932.2 → XP_011240234.1  anaphase-promoting complex subunit 15 isoform X1

      See identical proteins and their annotated locations for XP_011240234.1

      UniProtKB/TrEMBL
      G5E8M3
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    20. XM_006508279.3 → XP_006508342.1  anaphase-promoting complex subunit 15 isoform X1

      See identical proteins and their annotated locations for XP_006508342.1

      UniProtKB/TrEMBL
      G5E8M3
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    21. XM_011241933.2 → XP_011240235.1  anaphase-promoting complex subunit 15 isoform X1

      See identical proteins and their annotated locations for XP_011240235.1

      UniProtKB/TrEMBL
      G5E8M3
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    22. XM_030243049.2 → XP_030098909.1  anaphase-promoting complex subunit 15 isoform X3

      UniProtKB/Swiss-Prot
      P60007, Q3UT90, Q3UXV5
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    23. XM_030243054.1 → XP_030098914.1  anaphase-promoting complex subunit 15 isoform X4

      UniProtKB/TrEMBL
      A0A1W2P6Q9, H3BIU1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    24. XM_036153511.1 → XP_036009404.1  anaphase-promoting complex subunit 15 isoform X4

      UniProtKB/TrEMBL
      A0A1W2P6Q9, H3BIU1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    25. XM_036153509.1 → XP_036009402.1  anaphase-promoting complex subunit 15 isoform X3

      UniProtKB/Swiss-Prot
      P60007, Q3UT90, Q3UXV5
      UniProtKB/TrEMBL
      A0A1W2P6Q9
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    26. XM_036153508.1 → XP_036009401.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      Q9D3A0
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60007.1 GenPept UniProtKB/Swiss-Prot:P60007

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