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    Etfa electron transferring flavoprotein, alpha polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 110842, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Etfaprovided by MGI
    Official Full Name
    electron transferring flavoprotein, alpha polypeptideprovided by MGI
    Primary source
    MGI:MGI:106092
    See related
    Ensembl:ENSMUSG00000032314 AllianceGenome:MGI:106092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D9Ertd394e; 2010200I21Rik
    Summary
    Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity. Predicted to be involved in amino acid catabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; and respiratory electron transport chain. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFA (electron transfer flavoprotein subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 102.1), liver E18 (RPKM 85.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Etfa in Genome Data Viewer
    Location:
    9 B; 9 30.13 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55361720..55419528, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55454436..55512243, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene serpine1 mRNA binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9762 Neighboring gene transmembrane protein 266 Neighboring gene STARR-seq mESC enhancer starr_24189 Neighboring gene VISTA enhancer mm1754 Neighboring gene STARR-seq mESC enhancer starr_24190 Neighboring gene STARR-positive B cell enhancer ABC_E11406 Neighboring gene STARR-seq mESC enhancer starr_24191 Neighboring gene predicted gene 5917 Neighboring gene insulin related protein 2 (islet 2)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse neuronal apoptosis inhibitory protein gene maps to a conserved syntenic region of mouse chromosome 13. DiDonato CJ, et al. Mamm Genome, 1997 Mar. PMID 9069126
    2. Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation. Zhang X, et al. Proc Natl Acad Sci U S A, 2020 Feb 4. PMID 31941714, Free PMC Article
    3. cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein. Finocchiaro G, et al. Eur J Biochem, 1993 May 1. PMID 8504797
    4. A DEAD-family protein gene, Ddx4, encoding a murine homolog of Drosophila vasa maps to the distal end of mouse chromosome 13. Abe K, et al. Mamm Genome, 1997 Aug. PMID 9250878
    5. Cloning, characterization, and copy number of the murine survival motor neuron gene: homolog of the spinal muscular atrophy-determining gene. DiDonato CJ, et al. Genome Res, 1997 Apr. PMID 9110173

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic neddylation also enhances ETFA and ETFB expression in adult mice and prevents fasting-induced steatosis and mortality.
      Title: Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables electron transfer activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of electron transfer flavoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial electron transfer flavoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial matrix NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    electron transfer flavoprotein subunit alpha, mitochondrial
    Names
    Alpha-ETF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145615.4 → NP_663590.3  electron transfer flavoprotein subunit alpha, mitochondrial

      See identical proteins and their annotated locations for NP_663590.3

      Status: VALIDATED

      Source sequence(s)
      AK028118, AV289509, BC096645, BY435583
      Consensus CDS
      CCDS23204.1
      UniProtKB/Swiss-Prot
      Q3THD7, Q3V000, Q4V9X5, Q8BMD3, Q8BMU7, Q99LC5
      Related
      ENSMUSP00000034866.9, ENSMUST00000034866.9
      Conserved Domains (3) summary
      PLN00022
      Location:3 → 333
      PLN00022; electron transfer flavoprotein subunit alpha; Provisional
      cd01715
      Location:21 → 181
      ETF_alpha; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an ...
      pfam00766
      Location:211 → 293
      ETF_alpha; Electron transfer flavoprotein FAD-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      55361720..55419528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154563.1 → XP_036010456.1  electron transfer flavoprotein subunit alpha, mitochondrial isoform X1

      Conserved Domains (1) summary
      PLN00022
      Location:3 → 279
      PLN00022; electron transfer flavoprotein subunit alpha; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LC5.2 GenPept UniProtKB/Swiss-Prot:Q99LC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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