Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3cdprovided by MGI
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaprovided by MGI
Primary source: MGI:MGI:1098211
See related: Ensembl:ENSMUSG00000039936 AllianceGenome:MGI:1098211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p110delta; 2410099E07Rik; 2610208K16Rik
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of angiogenesis. Acts upstream of or within several processes, including B cell activation; B cell homeostasis; and defense response to fungus. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Predicted to be active in cytoplasm and plasma membrane. Is expressed in early embryo; hemolymphoid system; nervous system; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; immunodeficiency 14; and schizophrenia. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 42.3), thymus adult (RPKM 28.3) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 80.15 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (149733625..149787023, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (149649168..149702566, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Delta Isoform in Hepatocellular Proliferation.
Title: A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Delta Isoform in Hepatocellular Proliferation.
Activated PI3Kdelta Specifically Perturbs Mouse Regulatory T Cell Homeostasis and Function Leading to Immune Dysregulation.
Title: Activated PI3Kδ Specifically Perturbs Mouse Regulatory T Cell Homeostasis and Function Leading to Immune Dysregulation.
PI3Kdelta inhibition alleviates the brain injury during cerebral ischemia reperfusion via suppressing pericyte contraction in a TNF-alpha dependent manner.
Title: PI3Kδ inhibition alleviates the brain injury during cerebral ischemia reperfusion via suppressing pericyte contraction in a TNF-α dependent manner.
Oncogenic potential of PIK3CD in glioblastoma is exerted through cytoskeletal proteins PAK3 and PLEK2.
Title: Oncogenic potential of PIK3CD in glioblastoma is exerted through cytoskeletal proteins PAK3 and PLEK2.
DOCK2 and phosphoinositide-3 kinase delta mediate two complementary signaling pathways for CXCR5-dependent B cell migration.
Title: DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration.
Lack of Functional P110delta Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.
Title: Lack of Functional P110δ Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.
PI3Kdelta coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8(+) T cells at the expense of central memory.
Title: PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8(+) T cells at the expense of central memory.
Activated PI3Kdelta signals compromise plasma cell survival via limiting autophagy and increasing ER stress.
Title: Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress.
PI3K regulates the activation of NLRP3 inflammasome in atherosclerosis through part-dependent AKT signaling pathway.
Title: PI3K regulates the activation of NLRP3 inflammasome in atherosclerosis through part-dependent AKT signaling pathway.
Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naive Versus Effector CD8(+) T Cell Transcriptional Programs.
Title: Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naïve Versus Effector CD8(+) T Cell Transcriptional Programs.

Submit: New GeneRIF Correction See all GeneRIFs (105)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (4) 1 citation
Gene trapped (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235099

AW545373 (e-PCR)
- UniSTS:179115

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial tube formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Names: PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; catalytic phosphatidylinositol 3-kinase delta; p100 delta; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol 3-kinase catalytic subunit delta; phosphatidylinositol 3-kinase p110 delta; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphoinositide 3 kinase P110delta; ptdIns-3-kinase subunit delta; ptdIns-3-kinase subunit p110-delta

NP_001025008.2

EC 2.7.1.137

EC 2.7.1.153

NP_001157521.1

EC 2.7.1.137

EC 2.7.1.153

NP_001157522.1

EC 2.7.1.137

EC 2.7.1.153

NP_001157523.1

EC 2.7.1.137

EC 2.7.1.153

NP_001157524.1

EC 2.7.1.137

EC 2.7.1.153

NP_032866.2

EC 2.7.1.137

EC 2.7.1.153

XP_006538704.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538705.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538706.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538707.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538708.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538709.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538710.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538711.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538712.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538713.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538714.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538715.1

EC 2.7.1.137

EC 2.7.1.153

XP_006538716.1

EC 2.7.1.137

EC 2.7.1.153

XP_017175526.1

EC 2.7.1.137

EC 2.7.1.153

XP_017175527.1

EC 2.7.1.137

EC 2.7.1.153

XP_030109173.1

EC 2.7.1.137

EC 2.7.1.153

XP_030109174.1

EC 2.7.1.137

EC 2.7.1.153

XP_030109175.1

EC 2.7.1.137

EC 2.7.1.153

XP_036019722.1

EC 2.7.1.137

EC 2.7.1.153

XP_036019723.1

EC 2.7.1.137

EC 2.7.1.153

XP_036019724.1

EC 2.7.1.137

EC 2.7.1.153

XP_036019725.1

EC 2.7.1.137

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029837.2 → NP_001025008.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b

See identical proteins and their annotated locations for NP_001025008.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (b) includes an additional 3-aa internal segment, compared to isoform c. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AK040867, AK149935, AK153304, AW124359, CF164288

Consensus CDS

CCDS51384.1

UniProtKB/TrEMBL

Q3T9Y0, Q8BS14

Related

ENSMUSP00000136045.2, ENSMUST00000177654.8

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1045

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
NM_001164049.1 → NP_001157521.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b

See identical proteins and their annotated locations for NP_001157521.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (b) includes an additional 3-aa internal segment, compared to isoform c. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AL607078, AL626808

Consensus CDS

CCDS51384.1

UniProtKB/TrEMBL

Q3T9Y0, Q8BS14

Related

ENSMUSP00000101315.3, ENSMUST00000105690.9

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1045

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
NM_001164050.1 → NP_001157522.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform d

See identical proteins and their annotated locations for NP_001157522.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (d) includes an additional 1-aa internal segment, compared to isoform c.

Source sequence(s)

AL607078, AL626808

Consensus CDS

CCDS51383.1

UniProtKB/TrEMBL

B0QZL5, Q546P7, Q8BS14, Q8CI98

Related

ENSMUSP00000036434.8, ENSMUST00000038859.14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1043

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
NM_001164051.1 → NP_001157523.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform e

See identical proteins and their annotated locations for NP_001157523.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) represents use of an alternate promoter and 5' UTR, and uses two alternate in-frame splice sites in the central coding region, compared to variant 4. The resulting isoform (e) lacks a 1-aa internal segment and includes an additional 3-aa internal segments, compared to isoform c.

Source sequence(s)

AL607078

Consensus CDS

CCDS51381.1

UniProtKB/TrEMBL

Q3TBW3, Q8BS14

Related

ENSMUSP00000112863.2, ENSMUST00000118704.8

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 686

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:678 → 1044

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
NM_001164052.1 → NP_001157524.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a

See identical proteins and their annotated locations for NP_001157524.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site in the central coding region, compared to variant 4. The promoter and 5' UTR for this variant has not been determined. The resulting isoform (a) lacks a 1-aa internal segment, compared to isoform a.

Source sequence(s)

AL607078

Consensus CDS

CCDS51380.1

UniProtKB/Swiss-Prot

O35904, Q8CJ28

UniProtKB/TrEMBL

Q546P7

Related

ENSMUSP00000101314.2, ENSMUST00000105689.8

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 683

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:675 → 1041

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
NM_008840.3 → NP_032866.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform c

See identical proteins and their annotated locations for NP_032866.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes isoform c.

Source sequence(s)

AK040867, AK149935, AK153304, AL626808, AW124359

Consensus CDS

CCDS51382.1

UniProtKB/TrEMBL

B0QZL5, Q3UDT3, Q546P7, Q8BS14

Related

ENSMUSP00000101313.4, ENSMUST00000105688.10

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1042

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

149733625..149787023 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538646.1 → XP_006538709.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

See identical proteins and their annotated locations for XP_006538709.1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 713

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:705 → 1072

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538643.2 → XP_006538706.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

See identical proteins and their annotated locations for XP_006538706.1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 713

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:705 → 1072

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_017320037.2 → XP_017175526.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 713

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:705 → 1072

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538642.5 → XP_006538705.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

See identical proteins and their annotated locations for XP_006538705.1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 713

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:705 → 1072

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538648.5 → XP_006538711.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

See identical proteins and their annotated locations for XP_006538711.1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 712

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:704 → 1071

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538641.5 → XP_006538704.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

See identical proteins and their annotated locations for XP_006538704.1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 713

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:705 → 1072

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_036163829.1 → XP_036019722.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 713

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:705 → 1072

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_030253313.2 → XP_030109173.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X8

UniProtKB/TrEMBL

Q546P7

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 683

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:675 → 1042

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_017320038.3 → XP_017175527.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1046

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538650.5 → XP_006538713.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6

See identical proteins and their annotated locations for XP_006538713.1

UniProtKB/TrEMBL

B0QZL5, Q546P7, Q8BS14, Q8CI98

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1043

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538644.5 → XP_006538707.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

See identical proteins and their annotated locations for XP_006538707.1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 713

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:705 → 1072

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538645.1 → XP_006538708.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

See identical proteins and their annotated locations for XP_006538708.1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 713

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:705 → 1072

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538653.2 → XP_006538716.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X10

See identical proteins and their annotated locations for XP_006538716.1

Conserved Domains (3) summary

cd08693
Location:79 → 219

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:242 → 451

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:443 → 810

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
XM_036163832.1 → XP_036019725.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X13

Conserved Domains (3) summary

cd08693
Location:79 → 219

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:243 → 421

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:413 → 780

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
XM_030253314.2 → XP_030109174.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X11

Conserved Domains (3) summary

cd08693
Location:79 → 219

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:242 → 422

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:414 → 781

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
XM_036163830.1 → XP_036019723.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7

UniProtKB/TrEMBL

B0QZL5, Q3UDT3, Q546P7, Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1042

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538647.5 → XP_006538710.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

See identical proteins and their annotated locations for XP_006538710.1

UniProtKB/TrEMBL

Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 713

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:705 → 1071

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538652.5 → XP_006538715.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X9

See identical proteins and their annotated locations for XP_006538715.1

UniProtKB/Swiss-Prot

O35904, Q8CJ28

UniProtKB/TrEMBL

Q546P7

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 683

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:675 → 1041

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538651.4 → XP_006538714.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7

See identical proteins and their annotated locations for XP_006538714.1

UniProtKB/TrEMBL

B0QZL5, Q3UDT3, Q546P7, Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1042

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_006538649.4 → XP_006538712.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

See identical proteins and their annotated locations for XP_006538712.1

UniProtKB/TrEMBL

Q3T9Y0, Q8BS14

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:504 → 687

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:679 → 1045

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:182 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_030253315.2 → XP_030109175.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X14

Conserved Domains (3) summary

cd08693
Location:79 → 219

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:243 → 421

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:413 → 779

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
XM_036163831.1 → XP_036019724.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X12

Conserved Domains (3) summary

cd08693
Location:79 → 219

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:242 → 422

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:414 → 780

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta