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    Mrpl3 mitochondrial ribosomal protein L3 [ Mus musculus (house mouse) ]

    Gene ID: 94062, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrpl3provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L3provided by MGI
    Primary source
    MGI:MGI:2137204
    See related
    Ensembl:ENSMUSG00000032563 AllianceGenome:MGI:2137204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dcr; L3mt; 2010320L16Rik; 5930422H18Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; genitourinary system; liver; lung; and spleen. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 9. Orthologous to human MRPL3 (mitochondrial ribosomal protein L3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.7), placenta adult (RPKM 13.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl3 in Genome Data Viewer
    Location:
    9; 9 F1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (104930394..104954665)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (105053268..105077466)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57490 Neighboring gene copine IV Neighboring gene STARR-seq mESC enhancer starr_25118 Neighboring gene STARR-seq mESC enhancer starr_25120 Neighboring gene STARR-seq mESC enhancer starr_25121 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:105003152-105003421 Neighboring gene STARR-positive B cell enhancer ABC_E5099 Neighboring gene nudix hydrolase 16 like 2 Neighboring gene nudix hydrolase 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural Variant in Mitochondrial-Associated Gene (MRPL3) Induces Adult-Onset Neurodegeneration with Memory Impairment in the Mouse. Cahill LS, et al. J Neurosci, 2020 Jun 3. PMID 32341096, Free PMC Article
    2. A mouse model of heritable cerebrovascular disease. Sproule TJ, et al. PLoS One, 2010 Dec 31. PMID 21217823, Free PMC Article
    3. Cardiac deletion of Smyd2 is dispensable for mouse heart development. Diehl F, et al. PLoS One, 2010 Mar 17. PMID 20305823, Free PMC Article
    4. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
    5. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. Yagi M, et al. Nucleic Acids Res, 2012 Oct. PMID 22904065, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Variant in Mitochondrial-Associated Gene (MRPL3) Induces Adult-Onset Neurodegeneration with Memory Impairment in the Mouse.
      Title: Structural Variant in Mitochondrial-Associated Gene (MRPL3) Induces Adult-Onset Neurodegeneration with Memory Impairment in the Mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1)  1 citation
    • Targeted (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL3m
    Names
    39S ribosomal protein L3, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364512.1 → NP_001351441.1  large ribosomal subunit protein uL3m isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117688
      UniProtKB/TrEMBL
      Q05DC5
      Conserved Domains (1) summary
      cl00324
      Location:1 → 235
      Ribosomal_L3; Ribosomal protein L3

    2. NM_001364513.1 → NP_001351442.1  large ribosomal subunit protein uL3m isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK008592, AK054185
      Consensus CDS
      CCDS90652.1
      UniProtKB/TrEMBL
      D3Z456, Q91XB2
      Related
      ENSMUSP00000117547.2, ENSMUST00000149243.8
      Conserved Domains (1) summary
      cl00324
      Location:3 → 299
      Ribosomal_L3; Ribosomal protein L3

    3. NM_053159.4 → NP_444389.2  large ribosomal subunit protein uL3m isoform 1

      See identical proteins and their annotated locations for NP_444389.2

      Status: VALIDATED

      Source sequence(s)
      AC117688
      Consensus CDS
      CCDS23462.1
      UniProtKB/Swiss-Prot
      Q3TF66, Q99N95, Q9CVE4
      UniProtKB/TrEMBL
      Q91XB2
      Related
      ENSMUSP00000035177.9, ENSMUST00000035177.15
      Conserved Domains (2) summary
      TIGR03625
      Location:98 → 300
      L3_bact; 50S ribosomal protein uL3, bacterial form
      pfam00297
      Location:2 → 340
      Ribosomal_L3; Ribosomal protein L3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      104930394..104954665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155424.1 → XP_036011317.1  large ribosomal subunit protein uL3m isoform X1

      Conserved Domains (1) summary
      pfam00297
      Location:3 → 210
      Ribosomal_L3; Ribosomal protein L3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N95.1 GenPept UniProtKB/Swiss-Prot:Q99N95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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