Gzmk granzyme K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gzmkprovided by MGI
Official Full Name: granzyme Kprovided by MGI
Primary source: MGI:MGI:1298232
See related: Ensembl:ENSMUSG00000042385 AllianceGenome:MGI:1298232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space and secretory granule. Is expressed in several structures, including eye; forebrain; lung; small intestine; and spleen. Orthologous to human GZMK (granzyme K). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 63.93 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (113308164..113317499, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (113171630..113180965, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation.
Title: Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation.
Biological relevance of Granzymes A and K during E. coli sepsis.
Title: Biological relevance of Granzymes A and K during E. coli sepsis.
these data suggest that granzyme K does not play an essential role in viral immunity or cytotoxicity
Title: Granzyme K-deficient mice show no evidence of impaired antiviral immunity.
Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC).
Title: Substrate specificities of the granzyme tryptases A and K.
The data suggest that T-killer cells control lymphocytic choriomeningitis virus through non-cytotoxic processes that involve gzmK.
Title: Mouse granzyme K has pro-inflammatory potential.
It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1, Il6st, Gzmk, and Hspb3 genes' coexpression network.
Title: Map3k1, Il6st, Gzmk, and Hspb3 gene coexpression network in the mechanism of freezing reaction in mice.
grzK plays an important role in CD8(+) T-cell cytotoxicity both in the presence and absence of grzA and B.
Title: Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice.
GzmK-induced caspase-independent death occurs through Bid-dependent mitochondrial damage that is different from GzmA
Title: Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488258

Gzmk (e-PCR), detects polymorphism
- UniSTS:526211

Gzmk (e-PCR), detects polymorphism
- UniSTS:526212

Gzmk (e-PCR), detects polymorphism
- UniSTS:526213

Gzmk (e-PCR), detects polymorphism
- UniSTS:526214

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in granzyme-mediated programmed cell death signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: granzyme K

NP_032222.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008196.2 → NP_032222.1 granzyme K precursor

See identical proteins and their annotated locations for NP_032222.1

Status: VALIDATED

Source sequence(s)

AC139155

Consensus CDS

CCDS26783.1

UniProtKB/Swiss-Prot

O35205

UniProtKB/TrEMBL

A4FUV8

Related

ENSMUSP00000044512.8, ENSMUST00000038212.14

Conserved Domains (2) summary

smart00020
Location:25 → 253

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:26 → 256

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...