Wnt8b wingless-type MMTV integration site family, member 8B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt8bprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 8Bprovided by MGI
Primary source: MGI:MGI:109485
See related: Ensembl:ENSMUSG00000036961 AllianceGenome:MGI:109485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within negative regulation of gene expression and positive regulation of gene expression. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cochlea; eye; future brain; head mesenchyme; and nervous system. Human ortholog(s) of this gene implicated in Hirschsprung's disease. Orthologous to human WNT8B (Wnt family member 8B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 4.9), thymus adult (RPKM 1.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 37.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (44481912..44502712)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (44493472..44514273)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt8b regulates myofibroblast differentiation of lung-resident mesenchymal stem cells via the activation of Wnt/beta-catenin signaling in pulmonary fibrogenesis.
Title: Wnt8b regulates myofibroblast differentiation of lung-resident mesenchymal stem cells via the activation of Wnt/β-catenin signaling in pulmonary fibrogenesis.
mutual interactions between Gli3, Wnt8b, and Fgf17 are crucial elements of the balance between these factors thereby conferring robustness to the patterning process
Title: Direct Interactions Between Gli3, Wnt8b, and Fgfs Underlie Patterning of the Dorsal Telencephalon.
Wnt8b expression is up-regulated in the optic stalk of Foxg1(-/-) mutants before optic fissure closure initiates.
Title: The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk.
Neuroretina specification requires Six3-mediated suppression of Wnt8b a few hours later at the 6- to 8-somite stage.
Title: Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.
Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon.
Title: Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490767

Wnt8b (e-PCR), detects polymorphism
- UniSTS:465427

UniSTS:471332 (e-PCR)
- UniSTS:471332

Wnt8b (e-PCR), detects polymorphism
- UniSTS:471332

Wnt8b (e-PCR), detects polymorphism
- UniSTS:527146

UniSTS:277890 (e-PCR)
- UniSTS:277890

Wnt8b (e-PCR), detects polymorphism
- UniSTS:277890

Wnt8b (e-PCR), detects polymorphism
- UniSTS:144786

Wnt8b (e-PCR), detects polymorphism
- UniSTS:507326

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-8b

Names: wingless related MMTV integration site 8b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.