Mta3 metastasis associated 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mta3provided by MGI
Official Full Name: metastasis associated 3provided by MGI
Primary source: MGI:MGI:2151172
See related: Ensembl:ENSMUSG00000055817 AllianceGenome:MGI:2151172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1266; 1110002J22Rik
Summary: Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle and positive regulation of granulosa cell proliferation. Located in cytoplasm and nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human MTA3 (metastasis associated 1 family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 8.8), cerebellum adult (RPKM 8.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 54.53 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (84013483..84131144)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (83706163..83823715)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data are the first to disclose the presence and functional role of MTA3 in the testis, where its expression is regulated by developmental, metabolic, and hormonal cues and is closely associated with steroidogenic dysfunction. The
Title: Regulated and Functional Expression of the Corepressor MTA3 in Rodent Testis.
Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.
Title: Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.
Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.
Title: Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.
These results demonstrate the importance of FOG-2/MTA/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG repression motif and the NuRD complex.
Title: The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130014 (e-PCR)
- UniSTS:213302

NoName (e-PCR)
- UniSTS:237717

D17Mit162 (e-PCR), detects polymorphism
- UniSTS:127988

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of granulosa cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of granulosa cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell fate specification	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of stem cell differentiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuRD complex	ISO Inferred from Sequence Orthology more info
part_of NuRD complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NuRD complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metastasis-associated protein MTA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171052.1 → NP_001164523.1 metastasis-associated protein MTA3 isoform 1

See identical proteins and their annotated locations for NP_001164523.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

AC155160, AK146905

Consensus CDS

CCDS50196.1

UniProtKB/TrEMBL

Q3UII8, Q3UKM9

Related

ENSMUSP00000107971.4, ENSMUST00000112352.10

Conserved Domains (6) summary

smart00717
Location:269 → 316

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:375 → 426

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:377 → 425

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain
NM_001171053.1 → NP_001164524.1 metastasis-associated protein MTA3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the middle portion of the coding region and differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC155160, AK147197, BU756693, CA751287

Consensus CDS

CCDS50195.1

UniProtKB/TrEMBL

E9Q794, Q3UKM9

Related

ENSMUSP00000107968.3, ENSMUST00000112349.9

Conserved Domains (6) summary

smart00717
Location:269 → 316

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 427

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:378 → 426

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain
NM_001171054.1 → NP_001164525.1 metastasis-associated protein MTA3 isoform 4

See identical proteins and their annotated locations for NP_001164525.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC155160, AK147197, BU756693

Consensus CDS

CCDS50197.1

UniProtKB/TrEMBL

Q3U3A7, Q3UKM9

Related

ENSMUSP00000107969.2, ENSMUST00000112350.8

Conserved Domains (6) summary

smart00717
Location:269 → 316

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:375 → 426

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:377 → 425

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain
NM_001379388.1 → NP_001366317.1 metastasis-associated protein MTA3 isoform 8

Status: VALIDATED

Source sequence(s)

AC155160, AC155636

UniProtKB/TrEMBL

Q3UKM9

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 427

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:460 → 536

MTA_R1; MTA R1 domain
NM_001379389.1 → NP_001366318.1 metastasis-associated protein MTA3 isoform 5

Status: VALIDATED

Source sequence(s)

AC155160, AC155636

UniProtKB/TrEMBL

Q3UKM9

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 427

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:460 → 536

MTA_R1; MTA R1 domain
NM_001379390.1 → NP_001366319.1 metastasis-associated protein MTA3 isoform 9

Status: VALIDATED

Source sequence(s)

AC155160, AC155636

UniProtKB/TrEMBL

Q3UKM9

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:375 → 426

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:459 → 535

MTA_R1; MTA R1 domain
NM_001379391.1 → NP_001366320.1 metastasis-associated protein MTA3 isoform 6

Status: VALIDATED

Source sequence(s)

AC155160, AC155636

UniProtKB/TrEMBL

Q3UKM9

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:375 → 426

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:459 → 535

MTA_R1; MTA R1 domain
NM_001379392.1 → NP_001366321.1 metastasis-associated protein MTA3 isoform 7

Status: VALIDATED

Source sequence(s)

AC155160, AC155636

UniProtKB/TrEMBL

Q3UKM9

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 427

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:460 → 536

MTA_R1; MTA R1 domain
NM_054082.2 → NP_473423.1 metastasis-associated protein MTA3 isoform 2

See identical proteins and their annotated locations for NP_473423.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1.

Source sequence(s)

AC155160, AC155636, AK146905

Consensus CDS

CCDS28997.1

UniProtKB/Swiss-Prot

Q8VC18, Q924K8

UniProtKB/TrEMBL

Q3UKM9

Related

ENSMUSP00000068931.9, ENSMUST00000067826.15

Conserved Domains (6) summary

smart00717
Location:268 → 315

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:269 → 314

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:374 → 425

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:376 → 424

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 200

ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

84013483..84131144

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523511.3 → XP_006523574.1 metastasis-associated protein MTA3 isoform X4

UniProtKB/TrEMBL

Q3TY62

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 427

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:460 → 536

MTA_R1; MTA R1 domain
XM_006523506.2 → XP_006523569.1 metastasis-associated protein MTA3 isoform X1

UniProtKB/TrEMBL

Q3TY62

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:375 → 426

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:459 → 535

MTA_R1; MTA R1 domain
XM_006523509.4 → XP_006523572.1 metastasis-associated protein MTA3 isoform X2

UniProtKB/TrEMBL

Q3UKM9

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 427

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:460 → 536

MTA_R1; MTA R1 domain
XM_036160270.1 → XP_036016163.1 metastasis-associated protein MTA3 isoform X3

UniProtKB/TrEMBL

Q3UKM9

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:375 → 426

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:459 → 535

MTA_R1; MTA R1 domain