Macrod1 mono-ADP ribosylhydrolase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Macrod1provided by MGI
Official Full Name: mono-ADP ribosylhydrolase 1provided by MGI
Primary source: MGI:MGI:2147583
See related: Ensembl:ENSMUSG00000036278 AllianceGenome:MGI:2147583
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lrp16; D930010J01Rik
Summary: Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Predicted to be involved in DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Located in mitochondrion. Orthologous to human MACROD1 (mono-ADP ribosylhydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 26.0), adrenal adult (RPKM 22.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.17 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (7034065..7175427)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (7056728..7198062)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
Title: Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
These results suggest that LRP16 plays a key role in maintaining pancreatic beta-cell functions and may help us to understand the protective effects of estrogen on the functions of pancreatic beta-cells.
Title: Reduced expression of the LRP16 gene in mouse insulinoma (MIN6) cells exerts multiple effects on insulin content, proliferation and apoptosis.
LRP16 acts as a negative regulator of insulin action and adipogenesis in 3T3-L1 adipocytes.
Title: Identification of LRP16 as a negative regulator of insulin action and adipogenesis in 3T3-L1 adipocytes.
LRP16 played important roles not only in insulin content and GSIS but also in the antilipotoxic effect mediated by Akt/FoxO1 signaling.
Title: LRP16 gene protects mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/FoxO1 signaling.
LRP16 gene causes insulin resistance in C2-C12 cells by inhibiting the IRS-1 signaling and the transcriptional activity of PPARgamma.
Title: [LRP16 gene causes insulin resistance in C2-C12 cells by inhibiting the IRS-1 signaling and the transcriptional activity of peroxisome proliferator actived receptor γ].

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW742165 (e-PCR)
- UniSTS:209409

AW743046 (e-PCR)
- UniSTS:209411

D19Mit94 (e-PCR), detects polymorphism
- UniSTS:128430

AI604841 (e-PCR)
- UniSTS:166121

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-ribosylglutamate hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ADP-ribosylglutamate hydrolase activity	ISO Inferred from Sequence Orthology more info
enables ADP-ribosylglutamate hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables O-acetyl-ADP-ribose deacetylase activity	IEA Inferred from Electronic Annotation more info
enables deacetylase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on glycosyl bonds	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on glycosyl bonds	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-glutamate ADP-deribosylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-glutamate ADP-deribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein de-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein de-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine nucleoside metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleoside metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleoside metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ADP-ribose glycohydrolase MACROD1

Names: MACRO domain containing 1; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase; [Protein ADP-ribosylglutamate] hydrolase MACROD1

NP_001365848.1

EC 3.1.1.106

NP_001365849.1

EC 3.1.1.106

NP_001390467.1

EC 3.1.1.106

NP_001390469.1

EC 3.1.1.106

NP_598908.2

EC 3.1.1.106

XP_006526626.1

EC 3.1.1.106

XP_036017267.1

EC 3.1.1.106

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378919.1 → NP_001365848.1 ADP-ribose glycohydrolase MACROD1 isoform 2

Status: VALIDATED

Source sequence(s)

AC109619, AC140307

Conserved Domains (1) summary

cd02908
Location:151 → 317

Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
NM_001378920.1 → NP_001365849.1 ADP-ribose glycohydrolase MACROD1 isoform 3

Status: VALIDATED

Source sequence(s)

AC109619

Conserved Domains (1) summary

cl00019
Location:151 → 170

Macro_SF; macrodomain superfamily
NM_001403538.1 → NP_001390467.1 ADP-ribose glycohydrolase MACROD1 isoform 5

Status: VALIDATED

Source sequence(s)

AC109619, AC140307
NM_001403540.1 → NP_001390469.1 ADP-ribose glycohydrolase MACROD1 isoform 4

Status: VALIDATED

Source sequence(s)

AC109619, AC140307
NM_134147.5 → NP_598908.2 ADP-ribose glycohydrolase MACROD1 isoform 1

See identical proteins and their annotated locations for NP_598908.2

Status: VALIDATED

Source sequence(s)

AC109619, AC140307

Consensus CDS

CCDS50376.1

UniProtKB/Swiss-Prot

Q922B1

Related

ENSMUSP00000039507.6, ENSMUST00000040261.7

Conserved Domains (2) summary

COG2110
Location:150 → 314

YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]

cd02908
Location:151 → 317

Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

7034065..7175427

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161374.1 → XP_036017267.1 ADP-ribose glycohydrolase MACROD1 isoform X1

Conserved Domains (1) summary

cd02908
Location:151 → 317

Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
XM_006526563.4 → XP_006526626.1 ADP-ribose glycohydrolase MACROD1 isoform X2

Conserved Domains (1) summary

cl00019
Location:149 → 306

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...