Sorcs2 sortilin-related VPS10 domain containing receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sorcs2provided by MGI
Official Full Name: sortilin-related VPS10 domain containing receptor 2provided by MGI
Primary source: MGI:MGI:1932289
See related: Ensembl:ENSMUSG00000029093 AllianceGenome:MGI:1932289
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1329
Summary: Involved in intracellular protein transport and long-term synaptic depression. Located in endosome membrane; plasma membrane; and postsynaptic density. Is expressed in several structures, including brain; future spinal cord; musculature; sensory organ; and spinal cord. Orthologous to human SORCS2 (sortilin related VPS10 domain containing receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 13.6), limb E14.5 (RPKM 13.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 19.14 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (36174524..36555541, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (36017180..36398197, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hippocampal SorCS2 overexpression represses chronic stress-induced depressive-like behaviors by promoting the BDNF-TrkB system.
Title: Hippocampal SorCS2 overexpression represses chronic stress-induced depressive-like behaviors by promoting the BDNF-TrkB system.
SorCS2 binds progranulin to regulate motor neuron development.
Title: SorCS2 binds progranulin to regulate motor neuron development.
Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
Title: Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
SorCS2 is required for social memory and trafficking of the NMDA receptor.
Title: SorCS2 is required for social memory and trafficking of the NMDA receptor.
THe sortilin and SorCS2 are extensively present in several distinct anatomical areas in the developing nervous system and are rarely co-expressed.
Title: Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment.
structural analysis of binding of NGF, proNGF, and proBDNF to SorCS2
Title: Structural insights into SorCS2-Nerve Growth Factor complex formation.
Results indicate that hearing loss and hair bundle defects are associated with SorCS2 (Sortilin-related VPS-10 domain containing protein) disruption.
Title: Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear.
SorCS2 is expressed in mesodermally derived tissues such as striated muscle, adipose tissue, ossifying bone and connective tissue.
Title: Spatiotemporal patterns of sortilin and SorCS2 localization during organ development.
SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis
Title: The three sorCS genes are differentially expressed and regulated by synaptic activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127225 (e-PCR)
- UniSTS:167434

D5Mit75 (e-PCR), detects polymorphism
- UniSTS:130614

RH125058 (e-PCR)
- UniSTS:161880

30.MMHAP29FLB6.seq (e-PCR)
- UniSTS:159367

D5Jcs30 (e-PCR), detects polymorphism
- UniSTS:478866

D5Jcs31 (e-PCR), detects polymorphism
- UniSTS:478867

UniSTS:478869 (e-PCR)
- UniSTS:478869

D5Jcs33 (e-PCR), detects polymorphism
- UniSTS:478869

UniSTS:478870 (e-PCR)
- UniSTS:478870

D5Jcs34 (e-PCR), detects polymorphism
- UniSTS:478870

D5Jcs76 (e-PCR), detects polymorphism
- UniSTS:478912

NoName (e-PCR)
- UniSTS:490742

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: VPS10 domain-containing receptor SorCS2

Names: VPS10 domain receptor protein SORCS 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030889.2 → NP_112151.2 VPS10 domain-containing receptor SorCS2 precursor

See identical proteins and their annotated locations for NP_112151.2

Status: VALIDATED

Source sequence(s)

AC127275, AK047881, AK053853, AY004316, CO428928, CV784176

Consensus CDS

CCDS19237.1

UniProtKB/Swiss-Prot

B2RSI2, B2RSI4, Q9EPR5

UniProtKB/TrEMBL

Q8CHA4

Related

ENSMUSP00000041828.8, ENSMUST00000037370.14

Conserved Domains (3) summary

smart00602
Location:170 → 776

VPS10; VPS10 domain

PHA03307
Location:1 → 130

PHA03307; transcriptional regulator ICP4; Provisional

pfam00801
Location:798 → 860

PKD; PKD domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

36174524..36555541 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504202.4 → XP_006504265.1 VPS10 domain-containing receptor SorCS2 isoform X1

UniProtKB/TrEMBL

Q8CHA4

Conserved Domains (3) summary

smart00602
Location:170 → 776

VPS10; VPS10 domain

PHA03307
Location:1 → 130

PHA03307; transcriptional regulator ICP4; Provisional

pfam00801
Location:798 → 860

PKD; PKD domain
XM_036165631.1 → XP_036021524.1 VPS10 domain-containing receptor SorCS2 isoform X3

UniProtKB/TrEMBL

Q8CHA4

Conserved Domains (2) summary

smart00602
Location:30 → 636

VPS10; VPS10 domain

pfam00801
Location:658 → 723

PKD; PKD domain
XM_036165630.1 → XP_036021523.1 VPS10 domain-containing receptor SorCS2 isoform X2

UniProtKB/TrEMBL

Q8CHA4

Conserved Domains (2) summary

smart00602
Location:30 → 636

VPS10; VPS10 domain

pfam00801
Location:658 → 723

PKD; PKD domain