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    Zfp93 zinc finger protein 93 [ Mus musculus (house mouse) ]

    Gene ID: 22755, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp93provided by MGI
    Official Full Name
    zinc finger protein 93provided by MGI
    Primary source
    MGI:MGI:107611
    See related
    Ensembl:ENSMUSG00000055305 AllianceGenome:MGI:107611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf235
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in bladder; central nervous system; female associated reproductive structure; and ureter. Orthologous to human ZNF235 (zinc finger protein 235). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 1.4), CNS E14 (RPKM 1.3) and 28 other tissues See more
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    Genomic context

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    See Zfp93 in Genome Data Viewer
    Location:
    7 A3; 7 10.27 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23967406..23977219)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24267984..24277794)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 109 Neighboring gene zinc finger protein 108 Neighboring gene STARR-seq mESC enhancer starr_18256 Neighboring gene predicted gene, 51471 Neighboring gene zinc finger protein 51 pseudogene Neighboring gene predicted gene, 50477

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of homologous XRCC1-linked zinc-finger gene families in human and mouse: evidence for orthologous genes. Shannon M, et al. Genomics, 1998 Apr 1. PMID 9570955
    2. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. Shannon M, et al. Genomics, 1996 Apr 1. PMID 8617494
    3. Identification of novel ARF binding proteins by two-hybrid screening. Tompkins V, et al. Cell Cycle, 2006 Mar. PMID 16582619
    4. Detailed comparative map of human chromosome 19q and related regions of the mouse genome. Stubbs L, et al. Genomics, 1996 Aug 1. PMID 8812484
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfp93 zinc finger protein 93
      Title: Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 235
    Names
    zfp-93

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360227.1 → NP_001347156.1  zinc finger protein 235 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159140
      Conserved Domains (3) summary
      COG5048
      Location:275 → 613
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:25 → 66
      KRAB; KRAB box

    2. NM_009567.4 → NP_033593.1  zinc finger protein 235 isoform 2

      See identical proteins and their annotated locations for NP_033593.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK132229
      Consensus CDS
      CCDS39828.1
      UniProtKB/Swiss-Prot
      Q3UKA3, Q61116, Q8CE70
      Related
      ENSMUSP00000104077.4, ENSMUST00000108438.10
      Conserved Domains (4) summary
      COG5048
      Location:257 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:315 → 335
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:608 → 632
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_153420.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC159140, BM935074

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      23967406..23977219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322143.2 → XP_017177632.1  zinc finger protein 235 isoform X1

      UniProtKB/Swiss-Prot
      Q3UKA3, Q61116, Q8CE70
      Conserved Domains (4) summary
      COG5048
      Location:257 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:315 → 335
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:608 → 632
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61116.1 GenPept UniProtKB/Swiss-Prot:Q61116

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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