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    Alg9 ALG9 alpha-1,2-mannosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 102580, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Alg9provided by MGI
    Official Full Name
    ALG9 alpha-1,2-mannosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1924753
    See related
    Ensembl:ENSMUSG00000032059 AllianceGenome:MGI:1924753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dibd1; 8230402H15Rik; B430313H07Rik
    Summary
    Predicted to enable dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity and dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cortical plate. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Il. Orthologous to human ALG9 (ALG9 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.7), CNS E18 (RPKM 8.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Alg9 in Genome Data Viewer
    Location:
    9 A5.3; 9 27.75 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50686570..50754939)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50775225..50843639)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3828 Neighboring gene STARR-positive B cell enhancer ABC_E9760 Neighboring gene cilia and flagella associated protein 68 Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene predicted gene, 57547 Neighboring gene STARR-seq mESC enhancer starr_24122 Neighboring gene STARR-positive B cell enhancer mm9_chr9:50664895-50665195 Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene predicted gene, 25558 Neighboring gene salt inducible kinase 2 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,2-mannosyltransferase ALG9
    Names
    asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
    asparagine-linked glycosylation 9 homolog (yeast, alpha 1,2 mannosyltransferase)
    asparagine-linked glycosylation 9 protein
    asparagine-linked glycosylation protein 9 homolog
    disrupted in bipolar disorder 1 homolog
    disrupted in bipolar disorder protein 1 homolog
    dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
    dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
    NP_598742.1
    XP_006509964.1
    XP_006509965.1
    XP_006509966.1
    XP_011240682.1
    XP_017168554.1
    XP_030099802.1
    XP_030099803.1
    XP_030099804.1
    XP_030099805.1
    XP_030099806.1
    XP_036010400.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133981.3 → NP_598742.1  alpha-1,2-mannosyltransferase ALG9

      See identical proteins and their annotated locations for NP_598742.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript for this locus.
      Source sequence(s)
      AC123614
      Consensus CDS
      CCDS23175.1
      UniProtKB/Swiss-Prot
      Q8BT44, Q8C378, Q8C7G0, Q8VDI9
      Related
      ENSMUSP00000034561.5, ENSMUST00000034561.11
      Conserved Domains (1) summary
      pfam03901
      Location:60 → 482
      Glyco_transf_22; Alg9-like mannosyltransferase family

    RNA

    1. NR_045601.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123614
      Related
      ENSMUST00000162073.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      50686570..50754939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509901.3 → XP_006509964.1  alpha-1,2-mannosyltransferase ALG9 isoform X1

      Conserved Domains (1) summary
      pfam03901
      Location:60 → 482
      Glyco_transf_22; Alg9-like mannosyltransferase family

    2. XM_006509902.3 → XP_006509965.1  alpha-1,2-mannosyltransferase ALG9 isoform X2

      Conserved Domains (1) summary
      pfam03901
      Location:60 → 441
      Glyco_transf_22; Alg9-like mannosyltransferase family

    3. XM_030243942.2 → XP_030099802.1  alpha-1,2-mannosyltransferase ALG9 isoform X3

      Conserved Domains (1) summary
      pfam03901
      Location:60 → 441
      Glyco_transf_22; Alg9-like mannosyltransferase family

    4. XM_030243944.2 → XP_030099804.1  alpha-1,2-mannosyltransferase ALG9 isoform X6

      Conserved Domains (1) summary
      cl21590
      Location:51 → 336
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    5. XM_030243943.1 → XP_030099803.1  alpha-1,2-mannosyltransferase ALG9 isoform X5

      Conserved Domains (1) summary
      cl21590
      Location:51 → 377
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    6. XM_030243945.1 → XP_030099805.1  alpha-1,2-mannosyltransferase ALG9 isoform X7

      Conserved Domains (1) summary
      cl21590
      Location:1 → 311
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    7. XM_006509903.5 → XP_006509966.1  alpha-1,2-mannosyltransferase ALG9 isoform X4

      Conserved Domains (1) summary
      cl21590
      Location:51 → 377
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    8. XM_030243946.1 → XP_030099806.1  alpha-1,2-mannosyltransferase ALG9 isoform X8

      Conserved Domains (1) summary
      cl21590
      Location:1 → 311
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    9. XM_036154507.1 → XP_036010400.1  alpha-1,2-mannosyltransferase ALG9 isoform X9

      Conserved Domains (1) summary
      cl21590
      Location:1 → 270
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    10. XM_017313065.2 → XP_017168554.1  alpha-1,2-mannosyltransferase ALG9 isoform X6

      Conserved Domains (1) summary
      cl21590
      Location:51 → 336
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    11. XM_011242380.4 → XP_011240682.1  alpha-1,2-mannosyltransferase ALG9 isoform X10

      Conserved Domains (1) summary
      cl21590
      Location:105 → 191
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDI9.1 GenPept UniProtKB/Swiss-Prot:Q8VDI9

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