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    Etv3 ets variant 3 [ Mus musculus (house mouse) ]

    Gene ID: 27049, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Etv3provided by MGI
    Official Full Name
    ets variant 3provided by MGI
    Primary source
    MGI:MGI:1350926
    See related
    Ensembl:ENSMUSG00000003382 AllianceGenome:MGI:1350926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pe1; METS
    Summary
    Enables DEAD/H-box RNA helicase binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Located in chromatin. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and thymus primordium. Orthologous to human ETV3 (ETS variant transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.5), mammary gland adult (RPKM 9.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Etv3 in Genome Data Viewer
    Location:
    3 F1; 3 38.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87432891..87447463)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87525577..87540158)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40084 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87239522-87239823 Neighboring gene Fc receptor-like 5 Neighboring gene STARR-seq mESC enhancer starr_08157 Neighboring gene STARR-seq mESC enhancer starr_08158 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87291959-87292260 Neighboring gene predicted gene, 40085 Neighboring gene STARR-positive B cell enhancer ABC_E7919 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87310398-87310698 Neighboring gene STARR-positive B cell enhancer ABC_E7920 Neighboring gene STARR-positive B cell enhancer ABC_E6067 Neighboring gene STARR-positive B cell enhancer ABC_E10189 Neighboring gene STARR-positive B cell enhancer ABC_E6068 Neighboring gene ets variant 3-like Neighboring gene predicted gene, 25167

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ets gene family. Macleod K, et al. Trends Biochem Sci, 1992 Jul. PMID 1502727
    2. The ETS family of oncogenic transcription factors in solid tumours. Sizemore GM, et al. Nat Rev Cancer, 2017 Jun. PMID 28450705
    3. PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. Klemsz M, et al. Genomics, 1994 Mar 15. PMID 8020980
    4. Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element. Bidder M, et al. Biochemistry, 2000 Aug 1. PMID 10913304
    5. Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3. Carlson SM, et al. Sci Signal, 2011 Oct 25. PMID 22028470, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that ETV3 (a member of the E twenty-six family of transcriptional regulators), was extensively phosphorylated on sites within canonical and noncanonical ERK motifs.
      Title: Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.
    2. The ETV3 expression was strongly induced by the STAT3 pathway regulated by IL-10 but not by STAT3 signaling activated by IL-6, which cannot activate the anti-inflammatory signaling pathway.
      Title: Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.
    3. ETS gene expression is an essential requirement for normal sensory neuron differentiation
      Title: A developmental switch in the response of DRG neurons to ETS transcription factor signaling.
    4. PE-1/METS is an antiproliferative Ets repressor factor induced by CREB-1/CREM-1 during macrophage differentiation
      Title: PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ETS translocation variant 3
    Names
    ETS domain transcriptional repressor PE1
    ETS-domain protein
    ets variant gene 3
    mitogenic Ets transcriptional suppressor METS

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083318.3 → NP_001076787.1  ETS translocation variant 3 isoform 1

      See identical proteins and their annotated locations for NP_001076787.1

      Status: VALIDATED

      Source sequence(s)
      AC139241
      Consensus CDS
      CCDS17453.1
      UniProtKB/Swiss-Prot
      G5E907, Q8R4Z4, Q9QZW1
      UniProtKB/TrEMBL
      Q3U1H6
      Related
      ENSMUSP00000127419.2, ENSMUST00000170036.8
      Conserved Domains (1) summary
      smart00413
      Location:34 → 120
      ETS; erythroblast transformation specific domain

    2. NM_001286844.2 → NP_001273773.1  ETS translocation variant 3 isoform 1

      See identical proteins and their annotated locations for NP_001273773.1

      Status: VALIDATED

      Source sequence(s)
      AC139241
      Consensus CDS
      CCDS17453.1
      UniProtKB/Swiss-Prot
      G5E907, Q8R4Z4, Q9QZW1
      UniProtKB/TrEMBL
      Q3U1H6
      Conserved Domains (1) summary
      smart00413
      Location:34 → 120
      ETS; erythroblast transformation specific domain

    3. NM_001359750.2 → NP_001346679.1  ETS translocation variant 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139241
      Conserved Domains (1) summary
      smart00413
      Location:34 → 120
      ETS; erythroblast transformation specific domain

    4. NM_001411078.1 → NP_001398007.1  ETS translocation variant 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139241

    5. NM_001411079.1 → NP_001398008.1  ETS translocation variant 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139241
      UniProtKB/TrEMBL
      D3YVU8
      Related
      ENSMUSP00000114047.2, ENSMUST00000117293.2

    6. NM_001411080.1 → NP_001398009.1  ETS translocation variant 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139241
      UniProtKB/TrEMBL
      D3YVU8

    7. NM_012051.5 → NP_036181.3  ETS translocation variant 3 isoform 1

      See identical proteins and their annotated locations for NP_036181.3

      Status: VALIDATED

      Source sequence(s)
      AC139241
      Consensus CDS
      CCDS17453.1
      UniProtKB/Swiss-Prot
      G5E907, Q8R4Z4, Q9QZW1
      UniProtKB/TrEMBL
      Q3U1H6
      Related
      ENSMUSP00000112915.2, ENSMUST00000119109.8
      Conserved Domains (1) summary
      smart00413
      Location:34 → 120
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87432891..87447463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4Z4.2 GenPept UniProtKB/Swiss-Prot:Q8R4Z4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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