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    Vps45 vacuolar protein sorting 45 [ Mus musculus (house mouse) ]

    Gene ID: 22365, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps45provided by MGI
    Official Full Name
    vacuolar protein sorting 45provided by MGI
    Primary source
    MGI:MGI:891965
    See related
    Ensembl:ENSMUSG00000015747 AllianceGenome:MGI:891965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mVps45
    Summary
    Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Located in Golgi membrane and endosome membrane. Human ortholog(s) of this gene implicated in severe congenital neutropenia 5. Orthologous to human VPS45 (vacuolar protein sorting 45 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.3), CNS E14 (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vps45 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.65 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95907144..95969715, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95999832..96059661, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9054 Neighboring gene pleckstrin homology domain containing, family O member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:95836233-95836533 Neighboring gene STARR-positive B cell enhancer ABC_E2674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95861936-95862045 Neighboring gene predicted gene, 54210 Neighboring gene STARR-positive B cell enhancer ABC_E6079 Neighboring gene predicted gene, 30044 Neighboring gene OTU domain containing 7B Neighboring gene STARR-positive B cell enhancer ABC_E4561

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of vacuolar protein sorting-45 (Vps45) on mouse chromosome 3. Mishra VS, et al. Mamm Genome, 1998 Jan. PMID 9434958
    2. Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45. Roccisana J, et al. Mol Biol Cell, 2013 Aug. PMID 23741049, Free PMC Article
    3. Mammalian VPS45 orchestrates trafficking through the endosomal system. Frey L, et al. Blood, 2021 Apr 8. PMID 33512427
    4. Identification of a mammalian Golgi Sec1p-like protein, mVps45. Tellam JT, et al. J Biol Chem, 1997 Mar 7. PMID 9045632
    5. Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking. Pevsner J, et al. Gene, 1996 Dec 12. PMID 8996080

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mammalian VPS45 orchestrates trafficking through the endosomal system.
      Title: Mammalian VPS45 orchestrates trafficking through the endosomal system.
    2. A crucial role for mVps45 in the delivery of GLUT4 into its specialized, insulin-regulated compartment.
      Title: Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 45
    Names
    vacuolar protein sorting protein 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013841.3 → NP_038869.1  vacuolar protein sorting-associated protein 45

      See identical proteins and their annotated locations for NP_038869.1

      Status: VALIDATED

      Source sequence(s)
      AC092855, BC058528
      Consensus CDS
      CCDS17628.1
      UniProtKB/Swiss-Prot
      P97390, Q91VK9
      UniProtKB/TrEMBL
      Q3THX4
      Related
      ENSMUSP00000015891.6, ENSMUST00000015891.6
      Conserved Domains (1) summary
      pfam00995
      Location:23 → 539
      Sec1; Sec1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95907144..95969715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240074.3 → XP_011238376.1  vacuolar protein sorting-associated protein 45 isoform X1

      Conserved Domains (1) summary
      pfam00995
      Location:23 → 367
      Sec1; Sec1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97390.1 GenPept UniProtKB/Swiss-Prot:P97390

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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