Nup210 nucleoporin 210 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nup210provided by MGI
Official Full Name: nucleoporin 210provided by MGI
Primary source: MGI:MGI:1859555
See related: Ensembl:ENSMUSG00000030091 AllianceGenome:MGI:1859555
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gp190; gp210; Pom210; 9830001L10
Summary: Predicted to be involved in protein-containing complex assembly. Located in nuclear envelope. Is expressed in several structures, including alimentary system; brain; lung; metanephros; and skin. Orthologous to human NUP210 (nucleoporin 210). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 32.3), spleen adult (RPKM 28.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 40.3 cM

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (90990049..91095920, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (91013067..91118322, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity.
Title: Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity.
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.
Title: Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.
These results identified a Nup210 mutation in a mouse strain altered CD4/CD8 T cell ratios. Through the generation of Nup210 knockout mice was identified that Nup210 is having a T cell-intrinsic function in the peripheral homeostasis of T cells.
Title: Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
Our results uncover an unexpected role for Nup210 as a cell-intrinsic regulator of TCR signaling and T cell homeostasis
Title: Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4(+) T cell homeostasis.
The role of gp210/Nup210 in cell differentiation is mediated by its large luminal domain.
Title: The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis.
WT1 is probably not regulating GP210 expression, in spite of binding sites for WT1
Title: Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210.
Expression of gp210 mRNA and protein was seen in mouse embryonic stem (ES) cells, supporting the view of cell-type specific NPCs in metazoans and suggesting the gp210 gene is regulated by specific control elements not shared by other nucleoporins.
Title: Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.
gp210 cannot be required for incorporation of proteins or be required for maintaining nuclear pore complex stability.
Title: Dynamic properties of nuclear pore complex proteins in gp210 deficient cells.
Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation
Title: Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:224278 (e-PCR)
- UniSTS:224278

AI836801 (e-PCR)
- UniSTS:179419

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info	PubMed
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: nuclear pore membrane glycoprotein 210

Names: nuclear envelope pore membrane protein POM 210; nuclear pore membrane protein 210; nuclear pore protein gp210; nucleoporin 210; nuclear pore membrane glycoprotein 210; nuclear pore membrane protein 210; nucleoporin Nup210; pore membrane protein of 210 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018815.2 → NP_061285.2 nuclear pore membrane glycoprotein 210 precursor

See identical proteins and their annotated locations for NP_061285.2

Status: VALIDATED

Source sequence(s)

AK053417, AK173056, DT908828

Consensus CDS

CCDS39565.1

UniProtKB/Swiss-Prot

Q3U031, Q69ZW2, Q7TQM1, Q9QY81

UniProtKB/TrEMBL

A0A0R4J1I6

Related

ENSMUSP00000032179.8, ENSMUST00000032179.14

Conserved Domains (1) summary

pfam02368
Location:1079 → 1152

Big_2; Bacterial Ig-like domain (group 2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

90990049..91095920 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506400.5 → XP_006506463.1 nuclear pore membrane glycoprotein 210 isoform X1

UniProtKB/TrEMBL

A0A0R4J1I6

Conserved Domains (1) summary

pfam02368
Location:1079 → 1152

Big_2; Bacterial Ig-like domain (group 2)