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    Sertad2 SERTA domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 58172, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sertad2provided by MGI
    Official Full Name
    SERTA domain containing 2provided by MGI
    Primary source
    MGI:MGI:1931026
    See related
    Ensembl:ENSMUSG00000049800 AllianceGenome:MGI:1931026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sei2; SEI-2; Kiaa0127; TRIP-Br2; MNCb-1504; mKIAA0127
    Summary
    Enables transcription coactivator activity. Acts upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human SERTAD2 (SERTA domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.4), lung adult (RPKM 9.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sertad2 in Genome Data Viewer
    Location:
    11 A3.1; 11 13.03 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (20493166..20603023)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (20543166..20653023)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39606 Neighboring gene predicted gene, 39607 Neighboring gene predicted gene, 32142 Neighboring gene STARR-positive B cell enhancer ABC_E5208 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6957 Neighboring gene aftiphilin Neighboring gene RIKEN cDNA 4930434J08 gene Neighboring gene STARR-seq mESC enhancer starr_28821 Neighboring gene STARR-seq mESC enhancer starr_28822 Neighboring gene STARR-positive B cell enhancer mm9_chr11:20694243-20694543 Neighboring gene predicted gene, 32213

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    PubMed 

    General protein information

    Preferred Names
    SERTA domain-containing protein 2
    Names
    PHD zinc finger- and bromodomain-interacting protein 2
    transcriptional regulator interacting with the PHD-bromodomain 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038625.1NP_001033714.1  SERTA domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001033714.1

      Status: VALIDATED

      Source sequence(s)
      AK146621, AL663115
      Consensus CDS
      CCDS24458.1
      UniProtKB/Swiss-Prot
      Q8C609, Q91WL3, Q925E5, Q9JJG5
      UniProtKB/TrEMBL
      Q3UGZ1
      Related
      ENSMUSP00000105215.3, ENSMUST00000109586.3
      Conserved Domains (1) summary
      pfam06031
      Location:4075
      SERTA; SERTA motif
    2. NM_001362867.1NP_001349796.1  SERTA domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK147674, AL663115
      Conserved Domains (1) summary
      pfam06031
      Location:4681
      SERTA; SERTA motif
    3. NM_021372.3NP_067347.2  SERTA domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_067347.2

      Status: VALIDATED

      Source sequence(s)
      AK142268, AK147674, AL663115
      Consensus CDS
      CCDS24458.1
      UniProtKB/Swiss-Prot
      Q8C609, Q91WL3, Q925E5, Q9JJG5
      UniProtKB/TrEMBL
      Q3UGZ1
      Related
      ENSMUSP00000090981.5, ENSMUST00000093292.11
      Conserved Domains (1) summary
      pfam06031
      Location:4075
      SERTA; SERTA motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      20493166..20603023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156871.1XP_036012764.1  SERTA domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C609, Q91WL3, Q925E5, Q9JJG5
      UniProtKB/TrEMBL
      Q3UGZ1
      Conserved Domains (1) summary
      pfam06031
      Location:4075
      SERTA; SERTA motif
    2. XM_006514766.5XP_006514829.1  SERTA domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006514829.1

      UniProtKB/Swiss-Prot
      Q8C609, Q91WL3, Q925E5, Q9JJG5
      UniProtKB/TrEMBL
      Q3UGZ1
      Related
      ENSMUSP00000105214.2, ENSMUST00000109585.2
      Conserved Domains (1) summary
      pfam06031
      Location:4075
      SERTA; SERTA motif