Trim59 tripartite motif-containing 59 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim59provided by MGI
Official Full Name: tripartite motif-containing 59provided by MGI
Primary source: MGI:MGI:1914199
See related: Ensembl:ENSMUSG00000034317 AllianceGenome:MGI:1914199
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mrf1; TSBF1; 2310035M22Rik; 2700022F13Rik
Summary: Enables ubiquitin protein ligase activity. Involved in innate immune response and negative regulation of viral entry into host cell. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and skin. Orthologous to human TRIM59 (tripartite motif containing 59). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E14 (RPKM 15.4), liver E14.5 (RPKM 12.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E1; 3 32.16 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (68942625..68952075, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (69035292..69044742, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM59 deficiency promotes M1 macrophage activation and inhibits colorectal cancer through the STAT1 signaling pathway.
Title: TRIM59 deficiency promotes M1 macrophage activation and inhibits colorectal cancer through the STAT1 signaling pathway.
TRIM59 suppresses the brain ischaemia/reperfusion injury and pyroptosis of microglial through mediating the ubiquitination of NLRP3.
Title: TRIM59 suppresses the brain ischaemia/reperfusion injury and pyroptosis of microglial through mediating the ubiquitination of NLRP3.
Tripartite motif containing 59 mediates protective anti-oxidative effects in intestinal injury through Nrf2 signaling.
Title: Tripartite motif containing 59 mediates protective anti-oxidative effects in intestinal injury through Nrf2 signaling.
TRIM59 expression is regulated by Sp1 and Nrf1 in LPS-activated macrophages through JNK signaling pathway.
Title: TRIM59 expression is regulated by Sp1 and Nrf1 in LPS-activated macrophages through JNK signaling pathway.
TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages.
Title: TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages.
TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages.
Title: TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages.
A vital role of TRIM59 as an anti-tumor effector molecule of BAMs.
Title: TRIM59: A membrane protein expressed on Bacillus Calmette-Guérin-activated macrophages that induces apoptosis of fibrosarcoma cells by direct contact.
Trim59 may be a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly.
Title: Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.
BCG increased membrane expression of TRIM59 through the TLR2/ TLR4/IRF5 pathway in RAW264.7 macrophage cell line.
Title: BCG Increased Membrane Expression of TRIM59 Through the TLR2/ TLR4/IRF5 Pathway in RAW264.7 Macrophages.
Trim59 might be an essential accessory molecule in mediating BCG-activated macrophages tumoricidal functions; and Trim59 is a phagocytosis-correlated molecule.
Title: A novel accessory molecule Trim59 involved in cytotoxicity of BCG-activated macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
NOT part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tripartite motif-containing protein 59

Names: RING finger 1; RING finger protein 1; tumor suppressor TSBF1 homolog

NP_080139.3

EC 2.3.2.27

XP_006501980.1

EC 2.3.2.27

XP_011238502.1

EC 2.3.2.27

XP_011238503.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428934.1 → NP_001415863.1 tripartite motif-containing protein 59

Status: VALIDATED

Source sequence(s)

AC122876

UniProtKB/Swiss-Prot

E9QKA7, Q922Y2, Q9CSP2, Q9CUD5, Q9D740
NM_001428935.1 → NP_001415864.1 tripartite motif-containing protein 59

Status: VALIDATED

Source sequence(s)

AC122876

UniProtKB/Swiss-Prot

E9QKA7, Q922Y2, Q9CSP2, Q9CUD5, Q9D740
NM_001428936.1 → NP_001415865.1 tripartite motif-containing protein 59

Status: VALIDATED

Source sequence(s)

AC122876

UniProtKB/Swiss-Prot

E9QKA7, Q922Y2, Q9CSP2, Q9CUD5, Q9D740
NM_025863.4 → NP_080139.3 tripartite motif-containing protein 59

See identical proteins and their annotated locations for NP_080139.3

Status: VALIDATED

Source sequence(s)

AC122876

Consensus CDS

CCDS17402.1

UniProtKB/Swiss-Prot

E9QKA7, Q922Y2, Q9CSP2, Q9CUD5, Q9D740

UniProtKB/TrEMBL

D3Z0I5

Related

ENSMUSP00000103432.2, ENSMUST00000107802.8

Conserved Domains (2) summary

cd16763
Location:5 → 60

RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

cd19790
Location:95 → 134

Bbox2_TRIM59_C-XI; B-box-type 2 zinc finger found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

68942625..68952075 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501917.4 → XP_006501980.1 tripartite motif-containing protein 59 isoform X1

Related

ENSMUSP00000120270.2, ENSMUST00000136512.3

Conserved Domains (2) summary

cd16763
Location:5 → 60

RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

cd19790
Location:95 → 134

Bbox2_TRIM59_C-XI; B-box-type 2 zinc finger found in tripartite motif-containing protein 59 (TRIM59) and similar proteins
XM_011240200.2 → XP_011238502.1 tripartite motif-containing protein 59 isoform X1

Conserved Domains (2) summary

cd16763
Location:5 → 60

RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

cd19790
Location:95 → 134

Bbox2_TRIM59_C-XI; B-box-type 2 zinc finger found in tripartite motif-containing protein 59 (TRIM59) and similar proteins
XM_011240201.4 → XP_011238503.1 tripartite motif-containing protein 59 isoform X1

Conserved Domains (2) summary

cd16763
Location:5 → 60

RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

cd19790
Location:95 → 134

Bbox2_TRIM59_C-XI; B-box-type 2 zinc finger found in tripartite motif-containing protein 59 (TRIM59) and similar proteins