Arpc1a actin related protein 2/3 complex, subunit 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arpc1aprovided by MGI
Official Full Name: actin related protein 2/3 complex, subunit 1Aprovided by MGI
Primary source: MGI:MGI:1928896
See related: Ensembl:ENSMUSG00000029621 AllianceGenome:MGI:1928896
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 41kDa; Sid32; Sid329; 0610010H08Rik; 1110030K07Rik
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Located in muscle cell projection membrane. Is active in glutamatergic synapse. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 113.1), CNS E18 (RPKM 73.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 85.0 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (145020679..145045566)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (145083869..145108756)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235365

RH124589 (e-PCR)
- UniSTS:161411

RH125677 (e-PCR)
- UniSTS:162457

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Arp2/3 protein complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in muscle cell projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 1A

Names: SOP2-like protein; sid 329

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019767.2 → NP_062741.1 actin-related protein 2/3 complex subunit 1A

See identical proteins and their annotated locations for NP_062741.1

Status: PROVISIONAL

Source sequence(s)

AC110556

Consensus CDS

CCDS19855.1

UniProtKB/Swiss-Prot

Q3UL75, Q9R0Q6

Related

ENSMUSP00000031625.9, ENSMUST00000031625.15

Conserved Domains (3) summary

COG2319
Location:1 → 362

WD40; WD40 repeat [General function prediction only]

sd00039
Location:11 → 50

7WD40; WD40 repeat [structural motif]

cl02567
Location:46 → 280

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...