Insig2 insulin induced gene 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Insig2provided by RGD
Official Full Name: insulin induced gene 2provided by RGD
Primary source: RGD:631417
See related: EnsemblRapid:ENSRNOG00000002478 AllianceGenome:RGD:631417
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxysterol binding activity and protein sequestering activity. Involved in response to fatty acid and response to insulin. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Biomarker of end stage renal disease. Orthologous to human INSIG2 (insulin induced gene 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 701.1), Heart (RPKM 119.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (35025160..35052937, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (32472390..32500139, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (37264818..37292718, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest expression of hepatocyte Insig1/Insig2a and Crebh/Creb3l3 (cAMP responsive element-binding protein 3-like 3 protein) can be up-regulated by dietary factors (here, dietary supplementation with hypotriglyceridemic R-alpha-lipoic acid).
Title: Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid.
Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.
Title: Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC303355P2 (e-PCR)
- UniSTS:272505

RH128587 (e-PCR)
- UniSTS:211895

RH142395 (e-PCR)
- UniSTS:231642

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables oxysterol binding	IEA Inferred from Electronic Annotation more info
enables oxysterol binding	ISO Inferred from Sequence Orthology more info
enables oxysterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein sequestering activity	IEA Inferred from Electronic Annotation more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SREBP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in SREBP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in SREBP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in SREBP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in SREBP-SCAP complex retention in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in SREBP-SCAP complex retention in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in SREBP-SCAP complex retention in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in SREBP-SCAP complex retention in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cranial suture morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cranial suture morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in middle ear morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to sterol depletion	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SREBP-SCAP-Insig complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SREBP-SCAP-Insig complex	IEA Inferred from Electronic Annotation more info
part_of SREBP-SCAP-Insig complex	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-induced gene 2 protein

Names: INSIG-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431260.1 → NP_001418189.1 insulin-induced gene 2 protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q80UA9
NM_001431261.1 → NP_001418190.1 insulin-induced gene 2 protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q80UA9
NM_001431262.1 → NP_001418191.1 insulin-induced gene 2 protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q80UA9
NM_001431263.1 → NP_001418192.1 insulin-induced gene 2 protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8L2Q1M5
NM_001431264.1 → NP_001418193.1 insulin-induced gene 2 protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8L2Q1M5
NM_178091.5 → NP_835192.1 insulin-induced gene 2 protein isoform 1

See identical proteins and their annotated locations for NP_835192.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q80UA9

Conserved Domains (1) summary

pfam07281
Location:31 → 211

INSIG; Insulin-induced protein (INSIG)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

35025160..35052937 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249668.5 → XP_006249730.1 insulin-induced gene 2 protein isoform X2

Conserved Domains (1) summary

pfam07281
Location:31 → 211

INSIG; Insulin-induced protein (INSIG)
XM_039090420.2 → XP_038946348.1 insulin-induced gene 2 protein isoform X1

Conserved Domains (1) summary

pfam07281
Location:31 → 215

INSIG; Insulin-induced protein (INSIG)
XM_006249667.5 → XP_006249729.1 insulin-induced gene 2 protein isoform X2

Related

ENSRNOP00000003391.6, ENSRNOT00000003391.7

Conserved Domains (1) summary

pfam07281
Location:31 → 211

INSIG; Insulin-induced protein (INSIG)
XM_039090419.2 → XP_038946347.1 insulin-induced gene 2 protein isoform X1

Conserved Domains (1) summary

pfam07281
Location:31 → 215

INSIG; Insulin-induced protein (INSIG)
XM_063272061.1 → XP_063128131.1 insulin-induced gene 2 protein isoform X2
XM_039090421.2 → XP_038946349.1 insulin-induced gene 2 protein isoform X1

UniProtKB/TrEMBL

A0A8L2Q1M5

Conserved Domains (1) summary

pfam07281
Location:31 → 215

INSIG; Insulin-induced protein (INSIG)
XM_063272062.1 → XP_063128132.1 insulin-induced gene 2 protein isoform X2