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    Pigk phosphatidylinositol glycan anchor biosynthesis, class K [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pigkprovided by RGD
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Kprovided by RGD
    Primary source
    RGD:1306753
    See related
    EnsemblRapid:ENSRNOG00000042359 AllianceGenome:RGD:1306753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GPI-anchor transamidase activity. Predicted to be involved in attachment of GPI anchor to protein. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 173.8), Liver (RPKM 164.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pigk in Genome Data Viewer
    Location:
    2q45
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (244289928..244375394)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241630021..241715493)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257911099..257997735)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NHP2-like protein 1 Neighboring gene adenylate kinase 5 Neighboring gene uncharacterized LOC120100977 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Neighboring gene uncharacterized LOC134485772

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins. Ohishi K, et al. Mol Biol Cell, 2000 May. PMID 10793132, Free PMC Article
    2. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. Ohishi K, et al. EMBO J, 2001 Aug 1. PMID 11483512, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GPI-anchor transamidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GPI-anchor transamidase
    Names
    phosphatidylinositol glycan, class K
    NP_001011953.1
    XP_008759771.1
    XP_038958046.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011953.1 → NP_001011953.1  GPI-anchor transamidase precursor

      See identical proteins and their annotated locations for NP_001011953.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083636
      UniProtKB/TrEMBL
      A0A8I5Y6Z7, A0A8I6AH05, A6HWM4, F1M7W4, Q5XIP2
      Related
      ENSRNOP00000076726.1, ENSRNOT00000102861.2
      Conserved Domains (1) summary
      cl00042
      Location:42 → 332
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      244289928..244375394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102118.2 → XP_038958046.1  GPI-anchor transamidase isoform X2

      UniProtKB/TrEMBL
      A6HWM5
      Conserved Domains (1) summary
      cl00042
      Location:42 → 217
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    2. XM_008761549.3 → XP_008759771.1  GPI-anchor transamidase isoform X1

      UniProtKB/TrEMBL
      A0A8J8YK78
      Related
      ENSRNOP00000104768.1, ENSRNOT00000123981.1
      Conserved Domains (1) summary
      cl00042
      Location:42 → 332
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    Nucleotide Protein Strain
    Heading Accession and Version

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