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    Rab11fip1 RAB11 family interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498650, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Rab11fip1provided by RGD
    Official Full Name
    RAB11 family interacting protein 1provided by RGD
    Primary source
    RGD:1562965
    See related
    EnsemblRapid:ENSRNOG00000058940 AllianceGenome:RGD:1562965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562965; Rab11-FIP1
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of adiponectin secretion and regulated exocytosis. Predicted to be located in cytosol. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human RAB11FIP1 (RAB11 family interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 112.8), Kidney (RPKM 46.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab11fip1 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (71589753..71620341)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (64886902..64917491)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (69048739..69079332)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene adrenoceptor beta 3 Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene BRF2 general transcription factor 3B subunit Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene uncharacterized LOC134482405

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells. Eva R, et al. J Neurosci, 2010 Sep 1. PMID 20810886, Free PMC Article
    2. The rab11 effector protein FIP1 regulates adiponectin trafficking and secretion. Carson BP, et al. PLoS One, 2013. PMID 24040321, Free PMC Article
    3. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An interaction with Rab11 is necessary for long-range targeting of beta1 integrins to the growth cone along axons and in neurons.
      Title: Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of adiponectin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of adiponectin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rab11 family-interacting protein 1
    Names
    RAB11 family interacting protein 1 (class I)
    rab-coupling protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191555.1 → NP_001178484.1  rab11 family-interacting protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC107469, JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2JYK2
      Related
      ENSRNOP00000070687.1, ENSRNOT00000078128.3
      Conserved Domains (2) summary
      cd08682
      Location:20 → 150
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:1132 → 1179
      RBD-FIP; FIP domain

    2. NM_001197241.1 → NP_001184170.1  rab11 family-interacting protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BC107469, JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q3B7T9
      Related
      ENSRNOP00000073557.1, ENSRNOT00000086082.4
      Conserved Domains (2) summary
      cd08682
      Location:20 → 150
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:591 → 638
      RBD-FIP; FIP domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      71589753..71620341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094778.2 → XP_038950706.1  rab11 family-interacting protein 1 isoform X1

      Conserved Domains (3) summary
      PTZ00449
      Location:272 → 610
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:606 → 931
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam09457
      Location:981 → 1028
      RBD-FIP; FIP domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B7T9.1 GenPept UniProtKB/Swiss-Prot:Q3B7T9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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