Saraf store-operated calcium entry-associated regulatory factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sarafprovided by RGD
Official Full Name: store-operated calcium entry-associated regulatory factorprovided by RGD
Primary source: RGD:1303011
See related: EnsemblRapid:ENSRNOG00000012329 AllianceGenome:RGD:1303011
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem66
Summary: Predicted to be involved in regulation of store-operated calcium entry. Predicted to be located in endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SARAF (store-operated calcium entry associated regulatory factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 569.2), Lung (RPKM 415.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (64720404..64738653, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (58017231..58035481, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (61735189..61753438, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM66 attenuates neointimal hyperplasia after carotid artery injury by SOCE inactivation.
Title: Transmembrane protein 66 attenuates neointimal hyperplasia after carotid artery injury by SOCE inactivation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of store-operated calcium entry	IEA Inferred from Electronic Annotation more info
involved_in regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in regulation of store-operated calcium entry	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-plasma membrane contact site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-plasma membrane contact site	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: store-operated calcium entry-associated regulatory factor

Names: SOCE-associated regulatory factor; arrestin-E; transmembrane protein 66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004213.1 → NP_001004213.1 store-operated calcium entry-associated regulatory factor precursor

See identical proteins and their annotated locations for NP_001004213.1

Status: PROVISIONAL

Source sequence(s)

BC078979

UniProtKB/Swiss-Prot

Q6AYN2

UniProtKB/TrEMBL

A0A8L2Q907, A6IVP3

Related

ENSRNOP00000016792.7, ENSRNOT00000016792.8

Conserved Domains (1) summary

pfam06682
Location:25 → 334

SARAF; SOCE-associated regulatory factor of calcium homoeostasis