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    Matcap1 microtubule associated tyrosine carboxypeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Matcap1provided by RGD
    Official Full Name
    microtubule associated tyrosine carboxypeptidase 1provided by RGD
    Primary source
    RGD:1585272
    See related
    EnsemblRapid:ENSRNOG00000015625 AllianceGenome:RGD:1585272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Matcap; Kiaa0895l
    Summary
    Predicted to enable tubulin-tyrosine carboxypeptidase. Predicted to be involved in brain development. Predicted to be located in cytoplasm. Predicted to be active in microtubule. Orthologous to human MATCAP1 (microtubule associated tyrosine carboxypeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 59.9), Testes (RPKM 34.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Matcap1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50067978..50076715, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33158053..33166784, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37236484..37245217, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene phagophore assembly factor 1 Neighboring gene TNFRSF1A-associated via death domain Neighboring gene F-box and leucine-rich repeat protein 8 Neighboring gene heat shock transcription factor 4 Neighboring gene nucleolar protein 3 Neighboring gene exocyst complex component 3-like 1 Neighboring gene E2F transcription factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116202

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallocarboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tubulin-tyrosine carboxypeptidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin-tyrosine carboxypeptidase ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin-tyrosine carboxypeptidase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated tyrosine carboxypeptidase 1; microtubule-associated tyrosine carboxypeptidase
    NP_001037757.1
    XP_017456849.1
    XP_017456850.1
    XP_063134360.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044292.1 → NP_001037757.1  microtubule-associated tyrosine carboxypeptidase 1

      See identical proteins and their annotated locations for NP_001037757.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098942
      UniProtKB/Swiss-Prot
      Q4V7A9
      UniProtKB/TrEMBL
      A6IYN3, A6IYN4
      Related
      ENSRNOP00000020927.2, ENSRNOT00000020927.5
      Conserved Domains (1) summary
      cl06858
      Location:238 → 441
      DUF1704; Domain of unknown function (DUF1704)

    2. NM_001434606.1 → NP_001421535.1  microtubule-associated tyrosine carboxypeptidase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q4V7A9
      UniProtKB/TrEMBL
      A6IYN3, A6IYN4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50067978..50076715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601360.3 → XP_017456849.1  microtubule-associated tyrosine carboxypeptidase isoform X1

      Conserved Domains (1) summary
      cl06858
      Location:238 → 441
      DUF1704; Domain of unknown function (DUF1704)

    2. XM_017601361.2 → XP_017456850.1  microtubule-associated tyrosine carboxypeptidase isoform X1

      UniProtKB/Swiss-Prot
      Q4V7A9
      UniProtKB/TrEMBL
      A6IYN3, A6IYN4
      Conserved Domains (1) summary
      cl06858
      Location:238 → 441
      DUF1704; Domain of unknown function (DUF1704)

    3. XM_063278290.1 → XP_063134360.1  microtubule-associated tyrosine carboxypeptidase isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6S5, A6IYN4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7A9.1 GenPept UniProtKB/Swiss-Prot:Q4V7A9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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