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    Hmbox1 homeobox containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305968, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hmbox1provided by RGD
    Official Full Name
    homeobox containing 1provided by RGD
    Primary source
    RGD:1306787
    See related
    EnsemblRapid:ENSRNOG00000013326 AllianceGenome:RGD:1306787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306787
    Summary
    Predicted to enable double-stranded telomeric DNA binding activity; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; telomere maintenance via telomerase; and telomere-telomerase complex assembly. Predicted to be located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear body. Predicted to be active in nucleus. Orthologous to human HMBOX1 (homeobox containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 150.0), Kidney (RPKM 98.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hmbox1 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (43243503..43376011, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39067805..39200633, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48194709..48326310, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554677 Neighboring gene microRNA 124-1 Neighboring gene kinesin family member 13B Neighboring gene high mobility group nucleosomal binding domain 4, pseudogene 7 Neighboring gene integrator complex subunit 9 Neighboring gene uncharacterized LOC134482133 Neighboring gene exostosin-like glycosyltransferase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of Hmbox1 in endothelial differentiation of bone-marrow stromal cells by a small molecule. Su L, et al. ACS Chem Biol, 2010 Nov 19. PMID 20822188
    2. HMBOX1, homeobox transcription factor, negatively regulates interferon-γ production in natural killer cells. Wu L, et al. Int Immunopharmacol, 2011 Nov. PMID 21839858
    3. Characterization of a novel human HMBOX1 splicing variant lacking the homeodomain and with attenuated transcription repressor activity. Zhang M, et al. Mol Biol Rep, 2010 Jul. PMID 19757162
    4. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. Kappei D, et al. EMBO J, 2013 Jun 12. PMID 23685356, Free PMC Article
    5. DNA-binding specificities of human transcription factors. Jolma A, et al. Cell, 2013 Jan 17. PMID 23332764

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hmbox1 is a key factor in the differentiation of bone-marrow stromal cells in vascular endothelial cells.
      Title: Role of Hmbox1 in endothelial differentiation of bone-marrow stromal cells by a small molecule.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables double-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere-telomerase complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homeobox-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427100.2 → NP_001414029.1  homeobox-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6I6

    2. NM_001427101.2 → NP_001414030.1  homeobox-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6GJY0, A6K6I6
      Related
      ENSRNOP00000105983.1, ENSRNOT00000173136.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      43243503..43376011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094021.2 → XP_038949949.1  homeobox-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      D3ZER1
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    2. XM_039094013.2 → XP_038949941.1  homeobox-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A6K6I6
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    3. XM_039094010.2 → XP_038949938.1  homeobox-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A6K6I6
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    4. XM_039094020.2 → XP_038949948.1  homeobox-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      D3ZER1
      Related
      ENSRNOP00000092747.2, ENSRNOT00000120015.2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    5. XM_039094009.2 → XP_038949937.1  homeobox-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A6K6I6
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    6. XM_039094018.2 → XP_038949946.1  homeobox-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5Y5F7, D3ZER1
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    7. XM_039094017.2 → XP_038949945.1  homeobox-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5Y5F7, D3ZER1
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    8. XM_039094016.2 → XP_038949944.1  homeobox-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5Y5F7, D3ZER1
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    9. XM_039094008.2 → XP_038949936.1  homeobox-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6K6I6
      Related
      ENSRNOP00000110153.1, ENSRNOT00000129024.1
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    10. XM_063274287.1 → XP_063130357.1  homeobox-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A6K6I6

    11. XM_039094019.2 → XP_038949947.1  homeobox-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      D3ZER1
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    12. XM_039094015.2 → XP_038949943.1  homeobox-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      D3ZER1
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    13. XM_039094014.2 → XP_038949942.1  homeobox-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A3H7, A6K6I7, D3ZER1
      Related
      ENSRNOP00000029528.5, ENSRNOT00000038336.8
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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