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    Rngtt RNA guanylyltransferase and 5'-phosphatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rngttprovided by RGD
    Official Full Name
    RNA guanylyltransferase and 5'-phosphataseprovided by RGD
    Primary source
    RGD:1311410
    See related
    EnsemblRapid:ENSRNOG00000007867 AllianceGenome:RGD:1311410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable inorganic triphosphate phosphatase activity and mRNA guanylyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleus. Orthologous to human RNGTT (RNA guanylyltransferase and 5'-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 65.9), Spleen (RPKM 57.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rngtt in Genome Data Viewer
    Location:
    5q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (52503335..52709604)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47706929..47913297)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48561325..48779214)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350948 Neighboring gene proline-rich nuclear receptor coactivator 1 Neighboring gene eukaryotic initiation factor 4A-I pseudogene Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene uncharacterized LOC108350949 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108350950 Neighboring gene BCL2 interacting protein 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the guanylyltransferase domain of human mRNA capping enzyme. Chu C, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21636784, Free PMC Article
    2. Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. Tsukamoto T, et al. Biochem Biophys Res Commun, 1998 Feb 4. PMID 9473487
    3. Cap-binding complex (CBC). Gonatopoulos-Pournatzis T, et al. Biochem J, 2014 Jan 15. PMID 24354960, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inorganic triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 5'-triphosphate monophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA guanylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polynucleotide 5'-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA-capping enzyme
    NP_001101393.1
    XP_038965751.1
    XP_038965752.1
    XP_038965753.1
    XP_038965754.1
    XP_038965755.1
    XP_063143656.1
    XP_063143657.1
    XP_063143658.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107923.2 → NP_001101393.1  mRNA-capping enzyme

      See identical proteins and their annotated locations for NP_001101393.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IIL7, B5DFA8, D3ZH30
      Related
      ENSRNOP00000010614.2, ENSRNOT00000010614.7
      Conserved Domains (3) summary
      cd07895
      Location:248 → 461
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cd17664
      Location:9 → 175
      Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
      pfam03919
      Location:465 → 558
      mRNA_cap_C; mRNA capping enzyme, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      52503335..52709604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109825.2 → XP_038965753.1  mRNA-capping enzyme isoform X3

      UniProtKB/TrEMBL
      B5DFA8
      Conserved Domains (3) summary
      cd07895
      Location:188 → 401
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      pfam03919
      Location:405 → 498
      mRNA_cap_C; mRNA capping enzyme, C-terminal domain
      cl28904
      Location:1 → 115
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_063287587.1 → XP_063143657.1  mRNA-capping enzyme isoform X6

      UniProtKB/TrEMBL
      B5DFA8

    3. XM_063287586.1 → XP_063143656.1  mRNA-capping enzyme isoform X4

      UniProtKB/TrEMBL
      B5DFA8

    4. XM_039109826.2 → XP_038965754.1  mRNA-capping enzyme isoform X5

      UniProtKB/TrEMBL
      B5DFA8
      Conserved Domains (2) summary
      cd07895
      Location:248 → 461
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cd17664
      Location:9 → 175
      Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme

    5. XM_039109827.2 → XP_038965755.1  mRNA-capping enzyme isoform X8

      Conserved Domains (2) summary
      cd07895
      Location:248 → 419
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cd17664
      Location:9 → 175
      Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme

    6. XM_063287588.1 → XP_063143658.1  mRNA-capping enzyme isoform X7

    7. XM_039109824.2 → XP_038965752.1  mRNA-capping enzyme isoform X2

      UniProtKB/TrEMBL
      B5DFA8
      Related
      ENSRNOP00000074574.1, ENSRNOT00000091827.3
      Conserved Domains (3) summary
      cd07895
      Location:219 → 432
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cd17664
      Location:1 → 146
      Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
      pfam03919
      Location:436 → 529
      mRNA_cap_C; mRNA capping enzyme, C-terminal domain

    8. XM_039109823.2 → XP_038965751.1  mRNA-capping enzyme isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTT0, B5DFA8
      Related
      ENSRNOP00000082250.1, ENSRNOT00000095052.2
      Conserved Domains (3) summary
      cd07895
      Location:239 → 452
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      pfam03919
      Location:456 → 549
      mRNA_cap_C; mRNA capping enzyme, C-terminal domain
      cl28904
      Location:49 → 166
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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