Apba2 amyloid beta precursor protein binding family A member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apba2provided by RGD
Official Full Name: amyloid beta precursor protein binding family A member 2provided by RGD
Primary source: RGD:620845
See related: EnsemblRapid:ENSRNOG00000016358 AllianceGenome:RGD:620845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mint2
Summary: Enables amyloid-beta binding activity. Predicted to be involved in chemical synaptic transmission and presynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within in utero embryonic development; locomotory behavior; and regulation of gene expression. Is active in presynapse. Orthologous to human APBA2 (amyloid beta precursor protein binding family A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 244.4), Testes (RPKM 45.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (127465026..127698124)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (118053270..118286858)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (125367273..125547741)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that Mint2 may play more important role in spinal cord than the other two family members.
Title: Expression and ultrastructural localization of Mint2 in the spinal cord of rats.
Mint2 is a novel TrkA-regulating protein that affects NGF-induced neurite outgrowth, possibly through a mechanism involving retention of TrkA in the Golgi apparatus.
Title: Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth.
Upon neurodegeneration with okadaic acid, mint-1 and mint-2 levels were reduced by proteolytic cleavage, and these changes were followed by increases in APP levels.
Title: Reduction of mint-1, mint-2, and APP overexpression in okadaic acid-treated neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Rat45 (e-PCR)
- UniSTS:239753

AU028746 (e-PCR)
- UniSTS:112027

RH144418 (e-PCR)
- UniSTS:233663

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: amyloid-beta A4 precursor protein-binding family A member 2

Names: adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); neuron-specific X11L protein; neuronal Munc18-1-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031780.2 → NP_113968.1 amyloid-beta A4 precursor protein-binding family A member 2

See identical proteins and their annotated locations for NP_113968.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O35431

UniProtKB/TrEMBL

A6JBL8

Conserved Domains (4) summary

cd00992
Location:658 → 731

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:364 → 536

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:569 → 652

PDZ; PDZ domain (Also known as DHR or GLGF)

NF033845
Location:20 → 303

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

127465026..127698124

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092566.2 → XP_038948494.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

O35431

UniProtKB/TrEMBL

A6JBL8

Related

ENSRNOP00000022049.5, ENSRNOT00000022049.8

Conserved Domains (4) summary

cd00992
Location:658 → 731

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:364 → 536

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:569 → 652

PDZ; PDZ domain (Also known as DHR or GLGF)

NF033845
Location:20 → 303

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063275521.1 → XP_063131591.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6GKT7
XM_063275507.1 → XP_063131577.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

O35431

UniProtKB/TrEMBL

A6JBL8
XM_039092570.2 → XP_038948498.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

O35431

UniProtKB/TrEMBL

A6JBL8

Conserved Domains (4) summary

cd00992
Location:658 → 731

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:364 → 536

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:569 → 652

PDZ; PDZ domain (Also known as DHR or GLGF)

NF033845
Location:20 → 303

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063275551.1 → XP_063131621.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6GKT7
XM_039092563.2 → XP_038948491.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

O35431

UniProtKB/TrEMBL

A6JBL8

Conserved Domains (4) summary

cd00992
Location:658 → 731

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:364 → 536

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:569 → 652

PDZ; PDZ domain (Also known as DHR or GLGF)

NF033845
Location:20 → 303

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039092574.2 → XP_038948502.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6GKT7

Conserved Domains (3) summary

cd01208
Location:364 → 524

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:650 → 721

PDZ; PDZ domain (Also known as DHR or GLGF)

NF033845
Location:20 → 303

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039092571.2 → XP_038948499.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

O35431

UniProtKB/TrEMBL

A6JBL8

Conserved Domains (4) summary

cd00992
Location:658 → 731

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:364 → 536

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:569 → 652

PDZ; PDZ domain (Also known as DHR or GLGF)

NF033845
Location:20 → 303

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063275530.1 → XP_063131600.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6GKT7
XM_039092568.2 → XP_038948496.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

O35431

UniProtKB/TrEMBL

A6JBL8

Conserved Domains (4) summary

cd00992
Location:658 → 731

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:364 → 536

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:569 → 652

PDZ; PDZ domain (Also known as DHR or GLGF)

NF033845
Location:20 → 303

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063275517.1 → XP_063131587.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

O35431

UniProtKB/TrEMBL

A6JBL8
XM_063275541.1 → XP_063131611.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6GKT7

Related

ENSRNOP00000093806.1, ENSRNOT00000107834.2
XM_063275562.1 → XP_063131632.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3