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    Zbtb12 zinc finger and BTB domain containing 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309613, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zbtb12provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 12provided by RGD
    Primary source
    RGD:1302958
    See related
    EnsemblRapid:ENSRNOG00000071232 AllianceGenome:RGD:1302958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ng35
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB12 (zinc finger and BTB domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 17.9), Kidney (RPKM 13.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb12 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3942302..3945148, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3937668..3940514, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4572100..4574945)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098979 Neighboring gene solute carrier family 44, member 4 Neighboring gene euchromatic histone lysine methyltransferase 2 Neighboring gene complement C2 Neighboring gene complement factor B Neighboring gene negative elongation factor complex member E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC189499

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 12
    Names
    Ng35 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134991.2 → NP_001128463.1  zinc finger and BTB domain-containing protein 12

      See identical proteins and their annotated locations for NP_001128463.1

      Status: VALIDATED

      Source sequence(s)
      BC169087
      UniProtKB/TrEMBL
      B5DFJ8
      Related
      ENSRNOP00000098493.1, ENSRNOT00000120385.2
      Conserved Domains (6) summary
      COG5048
      Location:361 → 448
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:361 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18203
      Location:8 → 129
      BTB_POZ_ZBTB12; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12)
      pfam00096
      Location:359 → 381
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:373 → 398
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:333 → 382
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3942302..3945148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_002143.1: Suppressed sequence

      Description
      NR_002143.1: This RefSeq was permanently suppressed because it is now recognized that this locus encodes a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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