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    Drc1 dynein regulatory complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Drc1provided by RGD
    Official Full Name
    dynein regulatory complex subunit 1provided by RGD
    Primary source
    RGD:1359318
    See related
    EnsemblRapid:ENSRNOG00000024905 AllianceGenome:RGD:1359318
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc164
    Summary
    Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to act upstream of or within several processes, including cilium assembly; determination of left/right symmetry; and single fertilization. Predicted to be located in motile cilium. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme; cytosol; and sperm flagellum. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 21 and spermatogenic failure 80. Orthologous to human DRC1 (dynein regulatory complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 246.5), Lung (RPKM 36.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Drc1 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (31744849..31779996, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (26025004..26059438, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (27425237..27460038, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 2C Neighboring gene otoferlin Neighboring gene selenoprotein I Neighboring gene uncharacterized LOC120103489

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans. Wirschell M, et al. Nat Genet, 2013 Mar. PMID 23354437, Free PMC Article
    2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    3. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94915

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonemal dynein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axonemal dynein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axonemal dynein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium-dependent cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium-dependent cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium-dependent cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of axonemal dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein regulatory complex protein 1
    Names
    coiled-coil domain containing 164
    coiled-coil domain-containing protein 164
    dynein regulatory complex subunit 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007009.1 → NP_001007010.1  dynein regulatory complex protein 1

      See identical proteins and their annotated locations for NP_001007010.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083825
      UniProtKB/Swiss-Prot
      Q5XI65
      UniProtKB/TrEMBL
      A0A8I6AGD8
      Related
      ENSRNOP00000031362.4, ENSRNOT00000036815.7
      Conserved Domains (2) summary
      pfam14772
      Location:100 → 200
      NYD-SP28; Sperm tail
      pfam14775
      Location:674 → 732
      NYD-SP28_assoc; Sperm tail C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      31744849..31779996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112484.2 → XP_038968412.1  dynein regulatory complex protein 1 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:117 → 365
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam14772
      Location:100 → 200
      NYD-SP28; Sperm tail
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI65.1 GenPept UniProtKB/Swiss-Prot:Q5XI65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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