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    Spc24 SPC24 component of NDC80 kinetochore complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363028, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spc24provided by RGD
    Official Full Name
    SPC24 component of NDC80 kinetochore complexprovided by RGD
    Primary source
    RGD:1307631
    See related
    EnsemblRapid:ENSRNOG00000029862 AllianceGenome:RGD:1307631
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spbc24; Spc24-ps1; RGD1307631
    Summary
    Predicted to contribute to microtubule binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore. Predicted to be located in kinetochore; nucleolus; and nucleoplasm. Predicted to be part of Ndc80 complex. Orthologous to human SPC24 (SPC24 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 53.7), Spleen (RPKM 36.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spc24 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28576409..28581481, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20300315..20305354, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22780639..22785908, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 Neighboring gene uncharacterized LOC134480145 Neighboring gene low density lipoprotein receptor Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin-like 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene expression profiling in rat liver after VMH lesioning. Kiba T, et al. Exp Biol Med (Maywood), 2009 Jul. PMID 19429849
    2. Identification of two novel components of the human NDC80 kinetochore complex. Bharadwaj R, et al. J Biol Chem, 2004 Mar 26. PMID 14699129
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore protein Spc24
    Names
    SPC24, NDC80 kinetochore complex component, homolog, pseudogene 1
    spindle pole body component 24 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398872.1 → NP_001385801.1  kinetochore protein Spc24

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZPT0
      Related
      ENSRNOP00000045819.7, ENSRNOT00000045384.7
      Conserved Domains (2) summary
      TIGR02168
      Location:17 → 127
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam08286
      Location:83 → 192
      Spc24; Spc24 subunit of Ndc80

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28576409..28581481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082256.2 → XP_038938184.1  kinetochore protein Spc24 isoform X1

      UniProtKB/TrEMBL
      D4A1C5
      Conserved Domains (2) summary
      TIGR02168
      Location:17 → 127
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam08286
      Location:83 → 129
      Spc24; Spc24 subunit of Ndc80

    RNA

    1. XR_010053991.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials