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    Cbfa2t2 CBFA2/RUNX1 partner transcriptional co-repressor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cbfa2t2provided by RGD
    Official Full Name
    CBFA2/RUNX1 partner transcriptional co-repressor 2provided by RGD
    Primary source
    RGD:1309088
    See related
    EnsemblRapid:ENSRNOG00000016352 AllianceGenome:RGD:1309088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in several processes, including intestinal epithelial cell differentiation; negative regulation of DNA-templated transcription; and negative regulation of Notch signaling pathway. Predicted to act upstream of or within epithelial cell differentiation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 80.8), Adrenal (RPKM 80.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cbfa2t2 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (163397160..163503409)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (142936945..143043205)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (149935731..150041545)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene CDK5 regulatory subunit associated protein 1 Neighboring gene vomeromodulin-like Neighboring gene uncharacterized LOC120101761 Neighboring gene syntrophin, alpha 1 Neighboring gene spermine synthase, pseudogene 2 Neighboring gene ribosomal protein S10, pseudogene 7 Neighboring gene zinc finger FYVE-type containing 21, pseudogene 1 Neighboring gene similar to human chromosome 20 open reading frame 144 Neighboring gene N-terminal EF-hand calcium binding protein 3 Neighboring gene actin-like 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. Parang B, et al. FASEB J, 2015 Mar. PMID 25398765, Free PMC Article
    2. Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth. Ossovskaya VS, et al. J Neurosci Methods, 2009 Mar 15. PMID 19026687
    3. Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors. Cai Y, et al. Biochem Biophys Res Commun, 2009 Dec 11. PMID 19799863, Free PMC Article
    4. Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Amann JM, et al. Mol Cell Biol, 2005 Nov. PMID 16227606, Free PMC Article
    5. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. Barrett CW, et al. PLoS One, 2012. PMID 23251453, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intestinal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein CBFA2T2
    Names
    CBFA2/RUNX1 translocation partner 2
    core-binding factor, runt domain, alpha subunit 2
    core-binding factor, runt domain, alpha subunit 2; translocated to, 2
    translocated to, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168542.1 → NP_001162014.1  protein CBFA2T2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZYV9, A0A8I6A990
      Related
      ENSRNOP00000112518.1, ENSRNOT00000173645.1
      Conserved Domains (4) summary
      pfam01753
      Location:498 → 534
      zf-MYND; MYND finger
      pfam03763
      Location:430 → 481
      Remorin_C; Remorin, C-terminal region
      pfam07531
      Location:106 → 192
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:322 → 388
      NHR2; NHR2 domain like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      163397160..163503409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283368.1 → XP_063139438.1  protein CBFA2T2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A990

    2. XM_039104608.2 → XP_038960536.1  protein CBFA2T2 isoform X4

      UniProtKB/TrEMBL
      A6KHY8
      Conserved Domains (3) summary
      PRK00409
      Location:429 → 497
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam08788
      Location:322 → 388
      NHR2; NHR2 domain like
      pfam07531
      Location:106 → 194
      TAFH; NHR1 homology to TAF

    3. XM_006235311.5 → XP_006235373.1  protein CBFA2T2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A990
      Related
      ENSRNOP00000089665.2, ENSRNOT00000103275.2
      Conserved Domains (3) summary
      pfam01753
      Location:497 → 533
      zf-MYND; MYND finger
      pfam07531
      Location:106 → 192
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:322 → 388
      NHR2; NHR2 domain like

    4. XM_063283367.1 → XP_063139437.1  protein CBFA2T2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A990
      Related
      ENSRNOP00000084292.2, ENSRNOT00000106542.2
    Nucleotide Protein Strain
    Heading Accession and Version

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